TY - JOUR
T1 - The genetics of malignant melanoma
T2 - Lessons from mouse and man
AU - Chin, Lynda
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/8
Y1 - 2003/8
N2 - Therapeutic resistance and proclivity for metastasis are hallmarks of malignant melanoma. Genetic, epidemiological and genomic investigations are uncovering the spectrum of stereotypical mutations that are associated with melanoma and how these mutations relate to risk factors such as ultraviolet exposure. The ability to validate the pathogenetic relevance of these mutations in the mouse, coupled with advances in rational drug design, has generated optimism for the development of effective prevention programmes, diagnostic measures and targeted therapeutics in the near future.
AB - Therapeutic resistance and proclivity for metastasis are hallmarks of malignant melanoma. Genetic, epidemiological and genomic investigations are uncovering the spectrum of stereotypical mutations that are associated with melanoma and how these mutations relate to risk factors such as ultraviolet exposure. The ability to validate the pathogenetic relevance of these mutations in the mouse, coupled with advances in rational drug design, has generated optimism for the development of effective prevention programmes, diagnostic measures and targeted therapeutics in the near future.
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U2 - 10.1038/nrc1145
DO - 10.1038/nrc1145
M3 - Review article
C2 - 12894244
AN - SCOPUS:0042887050
SN - 1474-175X
VL - 3
SP - 559
EP - 570
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 8
ER -