The genetics of malignant melanoma: Lessons from mouse and man

Lynda Chin

Research output: Contribution to journalReview article

223 Citations (Scopus)

Abstract

Therapeutic resistance and proclivity for metastasis are hallmarks of malignant melanoma. Genetic, epidemiological and genomic investigations are uncovering the spectrum of stereotypical mutations that are associated with melanoma and how these mutations relate to risk factors such as ultraviolet exposure. The ability to validate the pathogenetic relevance of these mutations in the mouse, coupled with advances in rational drug design, has generated optimism for the development of effective prevention programmes, diagnostic measures and targeted therapeutics in the near future.

Original languageEnglish (US)
Pages (from-to)559-570
Number of pages12
JournalNature Reviews Cancer
Volume3
Issue number8
DOIs
StatePublished - Aug 1 2003

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Melanoma
Mutation
Aptitude
Drug Design
Neoplasm Metastasis
Therapeutics
Optimism

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The genetics of malignant melanoma : Lessons from mouse and man. / Chin, Lynda.

In: Nature Reviews Cancer, Vol. 3, No. 8, 01.08.2003, p. 559-570.

Research output: Contribution to journalReview article

Chin, Lynda. / The genetics of malignant melanoma : Lessons from mouse and man. In: Nature Reviews Cancer. 2003 ; Vol. 3, No. 8. pp. 559-570.
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