Abstract
Using cell-number-normalized transcriptome analysis, Lavado et al. show that inactivation of Hippo pathway LATS1/2 kinases during brain development causes YAP/TAZ-driven global hypertranscription, upregulating many genes involved in cell growth and proliferation. Hypertranscription in neural progenitors inhibits differentiation and triggers replication stress and DNA damage, resulting in massive apoptosis.
Original language | English (US) |
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Pages (from-to) | 576-591.e8 |
Journal | Developmental cell |
Volume | 47 |
Issue number | 5 |
DOIs | |
State | Published - Dec 3 2018 |
Keywords
- CNN RNA-seq
- ERCC normalization
- Hippo signaling
- Myc
- NanoString
- TEAD
- neural stem cells
- neurosphere
- radial glia
- transcriptional amplification
ASJC Scopus subject areas
- Molecular Biology
- General Biochemistry, Genetics and Molecular Biology
- Developmental Biology
- Cell Biology