The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

Alfonso Lavado, Jun Young Park, Joshua Paré, David Finkelstein, Haitao Pan, Beisi Xu, Yiping Fan, Ram Parikshan Kumar, Geoffrey Neale, Young Don Kwak, Peter J. McKinnon, Randy L. Johnson, Xinwei Cao

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Using cell-number-normalized transcriptome analysis, Lavado et al. show that inactivation of Hippo pathway LATS1/2 kinases during brain development causes YAP/TAZ-driven global hypertranscription, upregulating many genes involved in cell growth and proliferation. Hypertranscription in neural progenitors inhibits differentiation and triggers replication stress and DNA damage, resulting in massive apoptosis.

Original languageEnglish (US)
Pages (from-to)576-591.e8
JournalDevelopmental cell
Volume47
Issue number5
DOIs
StatePublished - Dec 3 2018

Keywords

  • CNN RNA-seq
  • ERCC normalization
  • Hippo signaling
  • Myc
  • NanoString
  • TEAD
  • neural stem cells
  • neurosphere
  • radial glia
  • transcriptional amplification

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology

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