The human vitronectin (complement S-protein) gene maps to the centromeric region of 17q

Thomas M. Fink, Dieter E. Jenne, Peter Lichter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Vitronectin (complement S-protein, serumspreading factor, epibolin) is a multifunctional glycoprotein that mediates cell-to-substrate adhesion, inhibits the cytolytic action of the terminal complement cascade in vitro and binds to several serine protease inhibitors of the serpin family, viz. antithrombin III, plasminogen activator inhibitor I (PAI-1) and II (PAI-2), heparin cofactor II and protease nexin. Using high resolution fluorescence in situ hybridization, we mapped the vitronectin gene to the centromeric region of the long arm of chromosome 17 corresponding to 17q11. The location was confirmed by co-hybridization with the centromerespecific alphoid probe p17H8 (D17Z1) and by chromosome banding with 4,6-diamidino-2-phenylindole-dihydrochloride (DAPI). None of the previously mapped genes that are evolutionary related to vitronectin are located on the same chromosome.

Original languageEnglish (US)
Pages (from-to)569-572
Number of pages4
JournalHuman genetics
Volume88
Issue number5
DOIs
StatePublished - Mar 1 1992

Fingerprint

Vitronectin
Complement System Proteins
Protease Nexins
Heparin Cofactor II
Plasminogen Activator Inhibitor 2
Chromosome Banding
Genes
Serpins
Plasminogen Inactivators
Chromosomes, Human, Pair 17
Serine Proteinase Inhibitors
Antithrombin III
Plasminogen Activator Inhibitor 1
Fluorescence In Situ Hybridization
Glycoproteins
Chromosomes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

The human vitronectin (complement S-protein) gene maps to the centromeric region of 17q. / Fink, Thomas M.; Jenne, Dieter E.; Lichter, Peter.

In: Human genetics, Vol. 88, No. 5, 01.03.1992, p. 569-572.

Research output: Contribution to journalArticle

Fink, Thomas M. ; Jenne, Dieter E. ; Lichter, Peter. / The human vitronectin (complement S-protein) gene maps to the centromeric region of 17q. In: Human genetics. 1992 ; Vol. 88, No. 5. pp. 569-572.
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