TY - JOUR
T1 - The immunotherapy landscape in adrenocortical cancer
AU - Pegna, Guillaume J.
AU - Roper, Nitin
AU - Kaplan, Rosandra N.
AU - Bergsland, Emily
AU - Kiseljak‐vassiliades, Katja
AU - Habra, Mouhammed Amir
AU - Pommier, Yves
AU - Del Rivero, Jaydira
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal gland that is frequently associated with excess production of adrenal hormones. Although surgical resection may be curative in early‐stage disease, few effective therapeutic options exist in the inoperable advanced or metastatic setting. Immunotherapies, inclusive of a broad array of immune‐activating and immunemodulating antineoplastic agents, have demonstrated clinical benefit in a wide range of solid and hematologic malignancies. Due to the broad activity across multiple cancer types, there is significant interest in testing these agents in rare tumors, including ACC. Multiple clinical trials evaluating immunotherapies for the treatment of ACC have been conducted, and many more are ongoing or planned. Immunotherapies that have been evaluated in clinical trials for ACC include the immune checkpoint inhibitors pembrolizumab, nivolumab, and avelumab. Other immunotherapies that have been evaluated include the monoclonal antibodies figitumumab and cixutumumab directed against the ACC‐expressed insulin‐like growth factor 1 (IGF‐1) receptor, the recombinant cytotoxin interleukin‐13‐pseudomonas exotoxin A, and autologous tumor lysate dendritic cell vaccine. These agents have shown modest clinical activity, although nonzero in the case of the immune checkpoint inhibitors. Clinical trials are ongoing to evaluate whether this clinical activity may be augmented through combinations with other immune‐acting agents or targeted therapies.
AB - Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal gland that is frequently associated with excess production of adrenal hormones. Although surgical resection may be curative in early‐stage disease, few effective therapeutic options exist in the inoperable advanced or metastatic setting. Immunotherapies, inclusive of a broad array of immune‐activating and immunemodulating antineoplastic agents, have demonstrated clinical benefit in a wide range of solid and hematologic malignancies. Due to the broad activity across multiple cancer types, there is significant interest in testing these agents in rare tumors, including ACC. Multiple clinical trials evaluating immunotherapies for the treatment of ACC have been conducted, and many more are ongoing or planned. Immunotherapies that have been evaluated in clinical trials for ACC include the immune checkpoint inhibitors pembrolizumab, nivolumab, and avelumab. Other immunotherapies that have been evaluated include the monoclonal antibodies figitumumab and cixutumumab directed against the ACC‐expressed insulin‐like growth factor 1 (IGF‐1) receptor, the recombinant cytotoxin interleukin‐13‐pseudomonas exotoxin A, and autologous tumor lysate dendritic cell vaccine. These agents have shown modest clinical activity, although nonzero in the case of the immune checkpoint inhibitors. Clinical trials are ongoing to evaluate whether this clinical activity may be augmented through combinations with other immune‐acting agents or targeted therapies.
KW - Adrenocortical carcinoma
KW - Immunotherapy
KW - Immuno‐oncology
UR - http://www.scopus.com/inward/record.url?scp=85106652689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106652689&partnerID=8YFLogxK
U2 - 10.3390/cancers13112660
DO - 10.3390/cancers13112660
M3 - Review article
C2 - 34071333
AN - SCOPUS:85106652689
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 11
M1 - 2660
ER -