TY - JOUR
T1 - The interaction between the complement system and hemostatic factors
AU - Oncul, Selin
AU - Afshar-Kharghan, Vahid
N1 - Funding Information:
The current work is supported by the R01CA231141 grant (V.A.-K.), 2R01CA177909 grant (V.A.-K.), American Society of Hematology Bridge Fund (V.A.-K.), and 2219-Research Grant as part of the International Postdoctoral Research Scholarship Program of Scientific and Technological Research Council of Turkey (TUBITAK) (S.O.).
Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Purpose of reviewTo discuss the crosstalk between the complement system and hemostatic factors (coagulation cascade, platelet, endothelium, and Von Willebrand Factor), and the consequences of this interaction under physiologic and pathologic conditions.Recent findingsThe complement and coagulation systems are comprised of serine proteases and are genetically related. In addition to the common ancestral genes, the complement system and hemostasis interact directly, through protein-protein interactions, and indirectly, on the surface of platelets and endothelial cells. The close interaction between the complement system and hemostatic factors is manifested both in physiologic and pathologic conditions, such as in the inflammatory response to thrombosis, thrombosis at the inflamed area, and thrombotic complications of complement disorders.SummaryThe interaction between the complement system and hemostasis is vital for homeostasis and the protective response of the host to tissue injury, but also results in the pathogenesis of several thrombotic and inflammatory disorders.
AB - Purpose of reviewTo discuss the crosstalk between the complement system and hemostatic factors (coagulation cascade, platelet, endothelium, and Von Willebrand Factor), and the consequences of this interaction under physiologic and pathologic conditions.Recent findingsThe complement and coagulation systems are comprised of serine proteases and are genetically related. In addition to the common ancestral genes, the complement system and hemostasis interact directly, through protein-protein interactions, and indirectly, on the surface of platelets and endothelial cells. The close interaction between the complement system and hemostatic factors is manifested both in physiologic and pathologic conditions, such as in the inflammatory response to thrombosis, thrombosis at the inflamed area, and thrombotic complications of complement disorders.SummaryThe interaction between the complement system and hemostasis is vital for homeostasis and the protective response of the host to tissue injury, but also results in the pathogenesis of several thrombotic and inflammatory disorders.
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U2 - 10.1097/MOH.0000000000000605
DO - 10.1097/MOH.0000000000000605
M3 - Review article
C2 - 32701617
AN - SCOPUS:85089127253
SN - 1065-6251
VL - 27
SP - 341
EP - 352
JO - Current opinion in hematology
JF - Current opinion in hematology
IS - 5
ER -