TY - JOUR
T1 - The Landmark Series
T2 - Preoperative Therapy for Pancreatic Cancer
AU - Patel, Sameer H.
AU - Katz, Matthew H.G.
AU - Ahmad, Syed A.
N1 - Publisher Copyright:
© 2021, Society of Surgical Oncology.
PY - 2021/8
Y1 - 2021/8
N2 - The surgical treatment of pancreas ductal adenocarcinoma (PDAC) is plagued by high rates of distant recurrences despite complete resection, highlighting the importance of systemic therapy. Historically, patients with PDAC have been treated with postoperative therapy, but this sequencing strategy can be associated with the inability to complete therapy due to perioperative complications and prolonged recovery. In addition, a subset of patients progress early, irrespective of whether surgery is performed, highlighting the systemic nature of this disease. Preoperative therapy has increasingly been utilized in clinical practice, but studies examining its benefits are limited. In this Landmark Series, we will review seminal studies for resectable and borderline resectable PDAC.
AB - The surgical treatment of pancreas ductal adenocarcinoma (PDAC) is plagued by high rates of distant recurrences despite complete resection, highlighting the importance of systemic therapy. Historically, patients with PDAC have been treated with postoperative therapy, but this sequencing strategy can be associated with the inability to complete therapy due to perioperative complications and prolonged recovery. In addition, a subset of patients progress early, irrespective of whether surgery is performed, highlighting the systemic nature of this disease. Preoperative therapy has increasingly been utilized in clinical practice, but studies examining its benefits are limited. In this Landmark Series, we will review seminal studies for resectable and borderline resectable PDAC.
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U2 - 10.1245/s10434-021-10075-1
DO - 10.1245/s10434-021-10075-1
M3 - Article
C2 - 34047859
AN - SCOPUS:85106731960
SN - 1068-9265
VL - 28
SP - 4104
EP - 4129
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 8
ER -