TY - JOUR
T1 - The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections
AU - Thakurdas, Shakeel M.
AU - Melicoff, Ernestina
AU - Sansores-Garcia, Leticia
AU - Moreira, Daniel C.
AU - Petrova, Youlia
AU - Stevens, Richard L.
AU - Adachi, Roberto
PY - 2007/7/20
Y1 - 2007/7/20
N2 - Although it has been shown that mast cell-deficient mice have diminished innate immune responses against bacteria, the most important immunoprotective factors secreted from activated mast cells have not been identified. Mouse mast cell protease 6 is a tetramer-forming tryptase. This serine protease is abundant in the secretory granules and is exocytosed upon bacterial challenge. Here we have described the generation of a mast cell protease-6-null mouse. Our discovery that mice lacking this neutral protease cannot efficiently clear Klebsiella pneumoniae from their peritoneal cavities reveals an essential role for this serine protease, and presumably its human ortholog, in innate immunity.
AB - Although it has been shown that mast cell-deficient mice have diminished innate immune responses against bacteria, the most important immunoprotective factors secreted from activated mast cells have not been identified. Mouse mast cell protease 6 is a tetramer-forming tryptase. This serine protease is abundant in the secretory granules and is exocytosed upon bacterial challenge. Here we have described the generation of a mast cell protease-6-null mouse. Our discovery that mice lacking this neutral protease cannot efficiently clear Klebsiella pneumoniae from their peritoneal cavities reveals an essential role for this serine protease, and presumably its human ortholog, in innate immunity.
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U2 - 10.1074/jbc.M611842200
DO - 10.1074/jbc.M611842200
M3 - Article
C2 - 17456473
AN - SCOPUS:34248194581
SN - 0021-9258
VL - 282
SP - 20809
EP - 20815
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 29
ER -