The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles

Maria Inês Almeida; George Adrian Calin

doi:10.1186/s13073-016-0284-1

The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles

Maria Inês Almeida, George Adrian Calin

Research output: Contribution to journal › Comment/debate › peer-review

31 Scopus citations

Abstract

miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.

Original language	English (US)
Article number	29
Journal	Genome medicine
Volume	8
Issue number	1
DOIs	https://doi.org/10.1186/s13073-016-0284-1
State	Published - Mar 17 2016

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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10.1186/s13073-016-0284-1

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title = "The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles",

abstract = "miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.",

author = "Almeida, {Maria In{\^e}s} and Calin, {George Adrian}",

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N2 - miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.

AB - miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.

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The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles

Abstract

ASJC Scopus subject areas

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