The myeloperoxidase gene is translocated from chromosome 17 to 15 in a patient with acute promyelocytic leukemia

Jan C. Liang; Kun Sang Chang; Wanda T. Schroeder; Emil J. Freireich; Sanford A. Stass; Jose M. Trujillo

doi:10.1016/0165-4608(88)90097-0

The myeloperoxidase gene is translocated from chromosome 17 to 15 in a patient with acute promyelocytic leukemia

Jan C. Liang
, Kun Sang Chang
, Wanda T. Schroeder
, Emil J. Freireich
, Sanford A. Stass
, Jose M. Trujillo

Leukemia

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

This study demonstrates that a differentiation-specific gene, the myeloperoxidase (MPO) gene, is translocated in a patient with acute promyelocytic leukemia (APL). The MPO gene recently has been mapped to chromosome #17, close to the breakpoint involved in the t(15;17) commonly seen in APL. By in situ hybridization, we showed that this gene was translocated from chromosome #17 to #15 in an APL patient. Although the significance of this translocation remains unclear, MPO is known to be highly expressed in APL. The causal relationship between the high expression and translocation of this gene requires further investigation.

Original language	English (US)
Pages (from-to)	103-107
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(88)90097-0
State	Published - Jan 1988

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/0165-4608(88)90097-0

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title = "The myeloperoxidase gene is translocated from chromosome 17 to 15 in a patient with acute promyelocytic leukemia",

abstract = "This study demonstrates that a differentiation-specific gene, the myeloperoxidase (MPO) gene, is translocated in a patient with acute promyelocytic leukemia (APL). The MPO gene recently has been mapped to chromosome \#17, close to the breakpoint involved in the t(15;17) commonly seen in APL. By in situ hybridization, we showed that this gene was translocated from chromosome \#17 to \#15 in an APL patient. Although the significance of this translocation remains unclear, MPO is known to be highly expressed in APL. The causal relationship between the high expression and translocation of this gene requires further investigation.",

author = "Liang, \{Jan C.\} and Chang, \{Kun Sang\} and Schroeder, \{Wanda T.\} and Freireich, \{Emil J.\} and Stass, \{Sanford A.\} and Trujillo, \{Jose M.\}",

note = "Funding Information: Supported in part by Grants CA43585 (\textbackslash{}].C.L.) and CA39809 (E.J.F.) awarded by the National Institute of Health, and RR5511-23 (K.S.C.). The authors appreciate the excellent secretarial assistance of Isabel Hernandez. Dr. Chang is a recipient of the Pennzoil Fellowship.",

year = "1988",

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doi = "10.1016/0165-4608(88)90097-0",

language = "English (US)",

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T1 - The myeloperoxidase gene is translocated from chromosome 17 to 15 in a patient with acute promyelocytic leukemia

AU - Liang, Jan C.

AU - Chang, Kun Sang

AU - Schroeder, Wanda T.

AU - Freireich, Emil J.

AU - Stass, Sanford A.

AU - Trujillo, Jose M.

N1 - Funding Information: Supported in part by Grants CA43585 (\].C.L.) and CA39809 (E.J.F.) awarded by the National Institute of Health, and RR5511-23 (K.S.C.). The authors appreciate the excellent secretarial assistance of Isabel Hernandez. Dr. Chang is a recipient of the Pennzoil Fellowship.

PY - 1988/1

Y1 - 1988/1

N2 - This study demonstrates that a differentiation-specific gene, the myeloperoxidase (MPO) gene, is translocated in a patient with acute promyelocytic leukemia (APL). The MPO gene recently has been mapped to chromosome #17, close to the breakpoint involved in the t(15;17) commonly seen in APL. By in situ hybridization, we showed that this gene was translocated from chromosome #17 to #15 in an APL patient. Although the significance of this translocation remains unclear, MPO is known to be highly expressed in APL. The causal relationship between the high expression and translocation of this gene requires further investigation.

AB - This study demonstrates that a differentiation-specific gene, the myeloperoxidase (MPO) gene, is translocated in a patient with acute promyelocytic leukemia (APL). The MPO gene recently has been mapped to chromosome #17, close to the breakpoint involved in the t(15;17) commonly seen in APL. By in situ hybridization, we showed that this gene was translocated from chromosome #17 to #15 in an APL patient. Although the significance of this translocation remains unclear, MPO is known to be highly expressed in APL. The causal relationship between the high expression and translocation of this gene requires further investigation.

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U2 - 10.1016/0165-4608(88)90097-0

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AN - SCOPUS:0023854890

SN - 0165-4608

VL - 30

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JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

The myeloperoxidase gene is translocated from chromosome 17 to 15 in a patient with acute promyelocytic leukemia

Abstract

ASJC Scopus subject areas

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