The neuroimmunology of chronic pain: From rodents to humans

Peter M. Grace; Vivianne L. Tawfik; Camilla I. Svensson; Michael D. Burton; Marco L. Loggia; Mark R. Hutchinson

doi:10.1523/JNEUROSCI.1650-20.2020

The neuroimmunology of chronic pain: From rodents to humans

Peter M. Grace, Vivianne L. Tawfik, Camilla I. Svensson, Michael D. Burton, Marco L. Loggia, Mark R. Hutchinson

Symptom Research CAO

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.

Original language	English (US)
Pages (from-to)	855-865
Number of pages	11
Journal	Journal of Neuroscience
Volume	41
Issue number	5
DOIs	https://doi.org/10.1523/JNEUROSCI.1650-20.2020
State	Published - Feb 3 2021

Keywords

Biomarkers
Cannabinoids
Fc gamma receptors
Nrf2
Sex differences
TSPO

ASJC Scopus subject areas

General Neuroscience

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10.1523/JNEUROSCI.1650-20.2020

Cite this

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abstract = "Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.",

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The neuroimmunology of chronic pain: From rodents to humans

Abstract

Keywords

ASJC Scopus subject areas

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