The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles

B. Hall, M. Andreeff, F. Marini

Research output: Chapter in Book/Report/Conference proceedingChapter

175 Scopus citations

Abstract

Recent evidence suggests that mesenchymal stem cells (MSC) selectively proliferate to tumors and contribute to the formation of tumor-associated stroma. The biological rationale for tumor recruitment of MSC remains unclear but may represent an effort of the host to blunt tumor cell growth and improve survival. There is mounting experimental evidence that normal stromal cells can revert malignant cell behavior, and separate studies have demonstrated that stromal cells can enhance tumor progression after acquisition of tumor-like genetic lesions. Together, these observations support the rationale for modifying normal MSC to deliver therapeutic proteins directly into the tumor microenvironment. Modified MSC can produce high concentrations of antitumor proteins directly within the Tumor mass, which have been shown to blunt tumor growth kinetics in experimental animal model systems. In this chapter we will address the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

Original languageEnglish (US)
Title of host publicationBone Marrow-Derived Progenitors
PublisherSpringer Science and Business Media, LLC
Pages263-283
Number of pages21
ISBN (Print)9783540689751
DOIs
StatePublished - 2007

Publication series

NameHandbook of Experimental Pharmacology
Volume180
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Desmoplasia
  • Mesenchymal Stem Cell (MSC)
  • Myofibroblast
  • Stromagenesis
  • Tumor Microenvironment
  • Tumor Stroma
  • Tumor-associated Fibroblast (TAF)

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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