The pathogenesis of cancer metastasis: Relevance to therapy

Sun Jin Kim, Cheryl Hunt Baker, Yasuhiko Kitadai, Toru Nakamura, Toshio Kuwai, Takamitsu Sasaki, Robert Langley, Isaiah J. Fidler

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Metastasis, the spread of malignant tumor cells from a primary neoplasm to distant parts of the body where they multiply to form new growths, is a major cause of death from cancer. The treatment of cancer poses a major problem to clinical oncologists, because by the time many cancers are diagnosed, metastasis may already have occurred, and the presence of multiple metastases makes complete eradication by surgery, radiation, drugs, or biotherapy nearly impossible. Metastases can be located in different organs and in different locations within the same organ. These aspects significantly influence the response of tumor cells to therapy and the efficiency of anticancer drugs, which must be delivered to tumor lesions to destroy cells without leading to undesirable side effects. Similarly, immune effector cells of current biotherapeu-tic regimens may not reach or localize in metastases with different organs.

Original languageEnglish (US)
Title of host publicationPrinciples of Cancer Biotherapy
Subtitle of host publication5th Edition
PublisherSpringer Netherlands
Pages17-40
Number of pages24
ISBN (Print)9789048122776
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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