TY - CHAP
T1 - The pathogenesis of cancer metastasis
T2 - Relevance to therapy
AU - Kim, Sun Jin
AU - Baker, Cheryl Hunt
AU - Kitadai, Yasuhiko
AU - Nakamura, Toru
AU - Kuwai, Toshio
AU - Sasaki, Takamitsu
AU - Langley, Robert
AU - Fidler, Isaiah J.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Metastasis, the spread of malignant tumor cells from a primary neoplasm to distant parts of the body where they multiply to form new growths, is a major cause of death from cancer. The treatment of cancer poses a major problem to clinical oncologists, because by the time many cancers are diagnosed, metastasis may already have occurred, and the presence of multiple metastases makes complete eradication by surgery, radiation, drugs, or biotherapy nearly impossible. Metastases can be located in different organs and in different locations within the same organ. These aspects significantly influence the response of tumor cells to therapy and the efficiency of anticancer drugs, which must be delivered to tumor lesions to destroy cells without leading to undesirable side effects. Similarly, immune effector cells of current biotherapeu-tic regimens may not reach or localize in metastases with different organs.
AB - Metastasis, the spread of malignant tumor cells from a primary neoplasm to distant parts of the body where they multiply to form new growths, is a major cause of death from cancer. The treatment of cancer poses a major problem to clinical oncologists, because by the time many cancers are diagnosed, metastasis may already have occurred, and the presence of multiple metastases makes complete eradication by surgery, radiation, drugs, or biotherapy nearly impossible. Metastases can be located in different organs and in different locations within the same organ. These aspects significantly influence the response of tumor cells to therapy and the efficiency of anticancer drugs, which must be delivered to tumor lesions to destroy cells without leading to undesirable side effects. Similarly, immune effector cells of current biotherapeu-tic regimens may not reach or localize in metastases with different organs.
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U2 - 10.1007/978-90-481-2289-9_2
DO - 10.1007/978-90-481-2289-9_2
M3 - Chapter
AN - SCOPUS:84901562198
SN - 9789048122776
SP - 17
EP - 40
BT - Principles of Cancer Biotherapy
PB - Springer Netherlands
ER -