The pathogenesis of systemic lupus erythematosus-an update

Jinyoung Choi; Sang Taek Kim; Joe Craft

doi:10.1016/j.coi.2012.10.004

The pathogenesis of systemic lupus erythematosus-an update

Jinyoung Choi, Sang Taek Kim, Joe Craft

Research output: Contribution to journal › Review article › peer-review

240 Scopus citations

Abstract

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

Original language	English (US)
Pages (from-to)	651-657
Number of pages	7
Journal	Current Opinion in Immunology
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.coi.2012.10.004
State	Published - Dec 2012
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.coi.2012.10.004

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title = "The pathogenesis of systemic lupus erythematosus-an update",

abstract = "Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.",

author = "Jinyoung Choi and Kim, {Sang Taek} and Joe Craft",

note = "Funding Information: This work was supported partly by NIH grants AR40072 , AR44076 , AI075157 , and AR053495 , and by the Alliance for Lupus Research . S. Kim was supported by a Research Scientist Development Award from the American College of Rheumatology Research and Education Foundation . ",

year = "2012",

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doi = "10.1016/j.coi.2012.10.004",

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AU - Kim, Sang Taek

AU - Craft, Joe

N1 - Funding Information: This work was supported partly by NIH grants AR40072 , AR44076 , AI075157 , and AR053495 , and by the Alliance for Lupus Research . S. Kim was supported by a Research Scientist Development Award from the American College of Rheumatology Research and Education Foundation .

PY - 2012/12

Y1 - 2012/12

N2 - Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

AB - Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

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The pathogenesis of systemic lupus erythematosus-an update

Abstract

ASJC Scopus subject areas

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