The pharmacological management of hairy cell leukemia

Jorge Ramos Perez, Farhad Ravandi-Kashani

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Introduction: Hairy cell leukemia (HCL) is a B-cell lymphoid malignancy that accounts for approximately 2% of all leukemias. Treatment with purine nucleoside analogs (PNA) results in a high response rate and remains the standard of care. Long term follow-up shows that most patients relapse and require retreatment. Newer combination strategies and agents have emerged to try to reduce the relapse rate and to address cases of PNA refractoriness. Areas covered: The authors reviewed the literature on the pharmacological management of HCL, including recent studies that led to new agents being incorporated into practice. Expert opinion: Combination of cladribine plus rituximab produces a high rate of measurable residual disease-negative complete remission. In our center, newly diagnosed patients are offered cladribine followed by 8 weekly doses of rituximab in an ongoing phase II trial. Patients in first relapse are also offered this combination if they were initially treated with a single-agent PNA, or if the remission duration was ≥5 years after first-line cladribine plus rituximab. Patients who relapse within 5 years are offered therapy with a novel agent that may include the BRAF inhibitor vemurafenib, alone or in combination with rituximab, dabrafenib in combination with trametinib, the BTK inhibitor ibrutinib, or moxetumomab pasudotox.

Original languageEnglish (US)
Pages (from-to)1337-1344
Number of pages8
JournalExpert opinion on pharmacotherapy
Volume21
Issue number11
DOIs
StatePublished - Jul 23 2020

Keywords

  • Hairy Cell Leukemia
  • cladribine
  • pharmacological management
  • rituximab

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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