The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation

Qinchao Hu, Tong Wu, Xiaobing Chen, Huan Li, Zhicheng Du, Yuantao Hao, Jianmin Peng, Shanshan Tai, Ming Song, Bin Cheng

Research output: Contribution to journalArticle

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Abstract

Radiotherapy for nasopharyngeal carcinoma has been reported to cause second primary oral squamous cell carcinoma (s-OSCC). The prognosis and pathologic characteristic of s-OSCC are largely unknown. Bmi1 was associated with the repair of radiation-induced DNA damage, suggesting its possible involvement in the pathologic process of s-OSCC. Herein, we compared the prognosis between s-OSCC and primary OSCC (p-OSCC) and explored the involvement of Bmi1 in s-OSCC development. In this retrospective study, s-OSCC and p-OSCC patients were matched by propensity scores. Their outcomes were compared by univariate and multivariate analyses. The expression of Bmi1 in s-OSCC and p-OSCC was detected by immunohistochemistry (IHC). Radiation-induced Bmi1 alteration in early-stage was explored in a rat model and HaCaT cells. After matching, 116 pairs of patients with highly balanced characteristics were included. In univariate analysis, the overall survival (OS), disease-specific survival (DSS), and local recurrence-free survival (LRFS) were poorer in s-OSCC than in p-OSCC (P < 0.05), while their regional metastasis-free survival (RMFS) was parallel (P = 0.112). Multivariate analysis further revealed that radiotherapy history was an independent risk factor for OS, DSS, and LRFS (P < 0.05). IHC results showed that the positive rate of Bmi1 was higher in s-OSCC (P = 0.0027). In a rat model of radiotherapy-induced mucositis, Bmi1 upregulation was observed 8 days after irradiation. Consistently, Bmi1 was upregulated in HaCaT cells 1 h after irradiation, and its upregulation was in accord with X-ray exposure duration. In conclusion, the prognosis of s-OSCC is poorer as compared to p-OSCC, which may be attributed to Bmi1 upregulation.

Original languageEnglish (US)
Pages (from-to)1056-1069
Number of pages14
JournalCancer medicine
Volume7
Issue number4
DOIs
StatePublished - Apr 2018

Fingerprint

Squamous Cell Carcinoma
Up-Regulation
Survival
Radiotherapy
Multivariate Analysis
Immunohistochemistry
Radiation
Recurrence
Propensity Score
Mucositis
Pathologic Processes
DNA Damage
Retrospective Studies
History
X-Rays
Neoplasm Metastasis

Keywords

  • Bmi1
  • nasopharyngeal carcinoma
  • oral squamous cell carcinoma
  • prognosis
  • radiotherapy
  • second primary tumor

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation. / Hu, Qinchao; Wu, Tong; Chen, Xiaobing; Li, Huan; Du, Zhicheng; Hao, Yuantao; Peng, Jianmin; Tai, Shanshan; Song, Ming; Cheng, Bin.

In: Cancer medicine, Vol. 7, No. 4, 04.2018, p. 1056-1069.

Research output: Contribution to journalArticle

Hu, Q, Wu, T, Chen, X, Li, H, Du, Z, Hao, Y, Peng, J, Tai, S, Song, M & Cheng, B 2018, 'The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation', Cancer medicine, vol. 7, no. 4, pp. 1056-1069. https://doi.org/10.1002/cam4.1348
Hu, Qinchao ; Wu, Tong ; Chen, Xiaobing ; Li, Huan ; Du, Zhicheng ; Hao, Yuantao ; Peng, Jianmin ; Tai, Shanshan ; Song, Ming ; Cheng, Bin. / The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation. In: Cancer medicine. 2018 ; Vol. 7, No. 4. pp. 1056-1069.
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