The prognostic value of preoperative prognostic nutritional index in patients with hypopharyngeal squamous cell carcinoma: A retrospective study

Lu Lu Ye, Ronald Wihal Oei, Fang Fang Kong, Cheng Run Du, Rui Ping Zhai, Qing Hai Ji, Chao Su Hu, Hong Mei Ying

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: To analyze the prognostic value of preoperative prognostic nutritional index (PNI) in predicting the survival outcome of hypopharyngeal squamous cell carcinoma (HPSCC) patients receiving radical surgery. Methods: From March 2006 to August 2016, 123 eligible HPSCC patients were reviewed. The preoperative PNI was calculated as serum albumin (g/dL)×10+total lymphocyte count (mm -3 )×0.005. These biomarkers were measured within 2weeks prior to surgery. The impact of preoperative PNI on overall survival (OS), progression-free survival (PFS), locoregional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) were analyzed using Kaplan-Meier method and Cox proportional hazards model. Results: Median value of 52.0 for the PNI was selected as the cutoff point. PNI value was then classified into two groups: high PNI (>52.0) versus low PNI (≤52.0). Multivariate analysis showed that high preoperative PNI was an independent prognostic factor for better OS (P=0.000), PFS (P=0.001), LRFS (P=0.005) and DMFS (P=0.016). Conclusions: High PNI predicts superior survival in HPSCC patients treated with radical surgery. As easily accessible biomarkers, preoperative PNI together with the conventional TNM staging system can be utilized to enhance the accuracy in predicting survival and determining therapy strategies in these patients.

Original languageEnglish (US)
Article number12
JournalJournal of translational medicine
Volume16
Issue number1
DOIs
StatePublished - Jan 24 2018

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Nutrition Assessment
Surgery
Squamous Cell Carcinoma
Retrospective Studies
Biomarkers
Survival
Lymphocytes
Serum Albumin
Hazards
Disease-Free Survival
Epithelial Cells
Neoplasm Metastasis
Recurrence
Neoplasm Staging
Nutritive Value
Lymphocyte Count
Proportional Hazards Models
Multivariate Analysis

Keywords

  • Hypopharyngeal squamous cell carcinoma
  • Prognosis
  • Prognostic nutritional index
  • Surgery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The prognostic value of preoperative prognostic nutritional index in patients with hypopharyngeal squamous cell carcinoma : A retrospective study. / Ye, Lu Lu; Oei, Ronald Wihal; Kong, Fang Fang; Du, Cheng Run; Zhai, Rui Ping; Ji, Qing Hai; Hu, Chao Su; Ying, Hong Mei.

In: Journal of translational medicine, Vol. 16, No. 1, 12, 24.01.2018.

Research output: Contribution to journalArticle

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abstract = "Background: To analyze the prognostic value of preoperative prognostic nutritional index (PNI) in predicting the survival outcome of hypopharyngeal squamous cell carcinoma (HPSCC) patients receiving radical surgery. Methods: From March 2006 to August 2016, 123 eligible HPSCC patients were reviewed. The preoperative PNI was calculated as serum albumin (g/dL)×10+total lymphocyte count (mm -3 )×0.005. These biomarkers were measured within 2weeks prior to surgery. The impact of preoperative PNI on overall survival (OS), progression-free survival (PFS), locoregional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) were analyzed using Kaplan-Meier method and Cox proportional hazards model. Results: Median value of 52.0 for the PNI was selected as the cutoff point. PNI value was then classified into two groups: high PNI (>52.0) versus low PNI (≤52.0). Multivariate analysis showed that high preoperative PNI was an independent prognostic factor for better OS (P=0.000), PFS (P=0.001), LRFS (P=0.005) and DMFS (P=0.016). Conclusions: High PNI predicts superior survival in HPSCC patients treated with radical surgery. As easily accessible biomarkers, preoperative PNI together with the conventional TNM staging system can be utilized to enhance the accuracy in predicting survival and determining therapy strategies in these patients.",
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AB - Background: To analyze the prognostic value of preoperative prognostic nutritional index (PNI) in predicting the survival outcome of hypopharyngeal squamous cell carcinoma (HPSCC) patients receiving radical surgery. Methods: From March 2006 to August 2016, 123 eligible HPSCC patients were reviewed. The preoperative PNI was calculated as serum albumin (g/dL)×10+total lymphocyte count (mm -3 )×0.005. These biomarkers were measured within 2weeks prior to surgery. The impact of preoperative PNI on overall survival (OS), progression-free survival (PFS), locoregional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) were analyzed using Kaplan-Meier method and Cox proportional hazards model. Results: Median value of 52.0 for the PNI was selected as the cutoff point. PNI value was then classified into two groups: high PNI (>52.0) versus low PNI (≤52.0). Multivariate analysis showed that high preoperative PNI was an independent prognostic factor for better OS (P=0.000), PFS (P=0.001), LRFS (P=0.005) and DMFS (P=0.016). Conclusions: High PNI predicts superior survival in HPSCC patients treated with radical surgery. As easily accessible biomarkers, preoperative PNI together with the conventional TNM staging system can be utilized to enhance the accuracy in predicting survival and determining therapy strategies in these patients.

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