Abstract
Lung branching morphogenesis generates a tree-like structure and allows efficient
airflow to millions of gas exchange units, the alveoli. The initiation, continuation,
and termination of lung branching morphogenesis require precise control
of the specification, maintenance, and depletion of lung epithelial progenitors.
Here I will focus on these progenitors and describe the branch morphology across
species and in comparison with other branching organs; the underlying cell biology
including polarity, movement, and matrix interaction; and an initial gene regulatory
network that can be expanded using genetic and genomic approaches. I will also
describe when and how branching ends and its implications in premature birth
and developmental plasticity.
airflow to millions of gas exchange units, the alveoli. The initiation, continuation,
and termination of lung branching morphogenesis require precise control
of the specification, maintenance, and depletion of lung epithelial progenitors.
Here I will focus on these progenitors and describe the branch morphology across
species and in comparison with other branching organs; the underlying cell biology
including polarity, movement, and matrix interaction; and an initial gene regulatory
network that can be expanded using genetic and genomic approaches. I will also
describe when and how branching ends and its implications in premature birth
and developmental plasticity.
| Original language | English (US) |
|---|---|
| Title of host publication | Stem Cells in the Lung |
| Subtitle of host publication | Development, Repair and Regeneration |
| Editors | Ivan Bertoncello |
| Publisher | Humana Press |
| Chapter | 1 |
| Pages | 3-16 |
| Number of pages | 14 |
| ISBN (Electronic) | 978-3-319-21082-7 |
| ISBN (Print) | 978-3-319-21081-0, 978-3-319-37170-2 |
| DOIs | |
| State | Published - 2015 |
Publication series
| Name | Stem Cell Biology and Regenerative Medicine |
|---|---|
| Publisher | Springer Cham |
| ISSN (Print) | 2196-8985 |
| ISSN (Electronic) | 2196-8993 |