TY - JOUR
T1 - The right drugs at the right time for the right patient
T2 - The MD Anderson precision oncology decision support platform
AU - Johnson, Amber
AU - Zeng, Jia
AU - Bailey, Ann M.
AU - Holla, Vijaykumar
AU - Litzenburger, Beate
AU - Lara-Guerra, Humberto
AU - Mills, Gordon B.
AU - Mendelsohn, John
AU - Shaw, Kenna R.
AU - Meric-Bernstam, Funda
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The development of resources for clinical interpretation of cancer-associated genetic alterations has significantly lagged behind the technical developments enabling their detection in a time- and cost-efficient manner. The lack of scientific and informatics decision support for oncologists can lead to no action being taken or suboptimal therapeutic choices being made, which could affect the clinical outcome of a patient as well as convoluting research findings from clinical trials. In this article, we describe the precision oncology decision support (PODS) platform developed within The Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy (IPCT) at MD Anderson Cancer Center; the platform aims to bridge the gap between molecular alteration detection and identification of appropriate treatments.
AB - The development of resources for clinical interpretation of cancer-associated genetic alterations has significantly lagged behind the technical developments enabling their detection in a time- and cost-efficient manner. The lack of scientific and informatics decision support for oncologists can lead to no action being taken or suboptimal therapeutic choices being made, which could affect the clinical outcome of a patient as well as convoluting research findings from clinical trials. In this article, we describe the precision oncology decision support (PODS) platform developed within The Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy (IPCT) at MD Anderson Cancer Center; the platform aims to bridge the gap between molecular alteration detection and identification of appropriate treatments.
UR - http://www.scopus.com/inward/record.url?scp=84949534750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949534750&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2015.05.013
DO - 10.1016/j.drudis.2015.05.013
M3 - Short survey
C2 - 26148707
AN - SCOPUS:84949534750
SN - 1359-6446
VL - 20
SP - 1433
EP - 1438
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 12
ER -