The role of A-to-I RNA editing in cancer development

Xiaoyan Xu, Yumeng Wang, Han Liang

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans, which is catalyzed in ADAR enzymes. Recent genomic studies have revealed thousands of altered RNA editing events in various cancer tissues, leading to diverse functional consequences. A critical role of individual A-to-I RNA editing events in cancer has been reported. Here, we review the current state of our knowledge on key A-to-I RNA editing events in coding and non-coding regions for their roles in cancer development and discuss their potential clinical utility. A better understanding of A-to-I RNA editing and its oncogenic mechanisms may facilitate the development of novel cancer therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume48
DOIs
StatePublished - Feb 2018

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

MD Anderson CCSG core facilities

  • Bioinformatics Shared Resource

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