TY - JOUR
T1 - The role of complex carbohydrate catabolism in the pathogenesis of invasive streptococci
AU - Shelburne, Samuel A.
AU - Davenport, Michael T.
AU - Keith, David B.
AU - Musser, James M.
N1 - Funding Information:
We thank K. Stockbauer for suggestions to improve the manuscript. This work was supported by American Heart Association grants 0565133Y and 0765115Y (S.A.S.) and National Institute Allergy and Infectious Diseases K08 Career Development Award AI-064564 (S.A.S.). We apologize to all authors whose work could not be included due to space limitations.
PY - 2008/7
Y1 - 2008/7
N2 - Historically, the study of bacterial catabolism of complex carbohydrates has contributed to understanding basic bacterial physiology. Recently, however, genome-wide screens of streptococcal pathogenesis have identified genes encoding proteins involved in complex carbohydrate catabolism as participating in pathogen infectivity. Subsequent studies have focused on specific mechanisms by which carbohydrate utilization proteins might contribute to the ability of streptococci to colonize and infect the host. Moreover, transcriptome and biochemical analyses have uncovered novel regulatory pathways by which streptococci link environmental carbohydrate availability to virulence factor production. Herein we review new insights into the role of complex carbohydrates in streptococcal host-pathogen interaction.
AB - Historically, the study of bacterial catabolism of complex carbohydrates has contributed to understanding basic bacterial physiology. Recently, however, genome-wide screens of streptococcal pathogenesis have identified genes encoding proteins involved in complex carbohydrate catabolism as participating in pathogen infectivity. Subsequent studies have focused on specific mechanisms by which carbohydrate utilization proteins might contribute to the ability of streptococci to colonize and infect the host. Moreover, transcriptome and biochemical analyses have uncovered novel regulatory pathways by which streptococci link environmental carbohydrate availability to virulence factor production. Herein we review new insights into the role of complex carbohydrates in streptococcal host-pathogen interaction.
UR - http://www.scopus.com/inward/record.url?scp=46049089600&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46049089600&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2008.04.002
DO - 10.1016/j.tim.2008.04.002
M3 - Review article
C2 - 18508271
AN - SCOPUS:46049089600
SN - 0966-842X
VL - 16
SP - 318
EP - 325
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 7
ER -