The role of dead-end in germ-cell tumor development

Rui Zhu, Chitralekha Bhattacharya, Angabin Matin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations


Testicular germ-cell tumors occur in human males of all age groups, from infants to men over 50 years old. Most commonly, germ-cell tumors (generally known as testicular cancer) occur in young males between the ages of 15 to 35 years. The tumor tissues are usually histologically diverse, and testicular tumors that occur in the different age groups tend to be of specific histological subtypes. Most germ-cell tumors originate from primordial germ cells during embryonic development, although the progression and eventual detection of the disease occurs decades later in humans. Mouse strains spontaneously develop a specific subtype of testicular germ-cell tumors, the type I germ-cell tumors, and these tumors are similar to the germ-cell tumors (or teratomas) that occur in human infants. Some mouse strains, such as the 129-Ter strain, have extremely high germ-cell tumor incidences, making such strains ideal for genetic and biological studies of germ cell-tumor development. Here a brief overview of the recently identified genetic defect in the Ter strain, inactivation of the dead-end (Dnd1) gene, and the ongoing studies on Dnd1 to understand its role in germ-cell and germ cell-tumor development, are provided.

Original languageEnglish (US)
Title of host publicationTesticular Chromosome Structure and Gene Expression
PublisherBlackwell Publishing Inc.
Number of pages6
ISBN (Print)9781573316934
StatePublished - Dec 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • 129 inbred strain
  • Dead end
  • Dnd1
  • Ter
  • Testicular germ-cell tumors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

MD Anderson CCSG core facilities

  • Genetically Engineered Mouse Facility


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