The role of glioma microenvironment in immune modulation: Potential targets for intervention

Mahua Dey; S. Farzana Hussain; Amy B. Heimberger

doi:10.2174/157018006778194844

The role of glioma microenvironment in immune modulation: Potential targets for intervention

Mahua Dey, S. Farzana Hussain, Amy B. Heimberger

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Malignant gliomas are associated with poor prognoses despite surgical, radiation and chemotherapy interventions. Since notable side-effects are associated with each of the aforementioned therapies, the future design of glioma immunotherapy clinical trials will need to address immune modulation at multiple levels for efficacious results. The review discusses emerging data that provides novel insights into immune modulation and their possible implications for immunotherapeutic approaches. The next generation of immunotherapy is largely focused on improving immune effector targeting and directing the tumor immune microenvironment to work synergistically with systematic immune activation.

Original language	English (US)
Pages (from-to)	443-453
Number of pages	11
Journal	Letters in Drug Design and Discovery
Volume	3
Issue number	7
DOIs	https://doi.org/10.2174/157018006778194844
State	Published - 2006

Keywords

Antigen presenting cells
Central nervous system
Dendritic cell
Glioblastoma multiforme
Microglia
Regulatory T cell

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

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10.2174/157018006778194844

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title = "The role of glioma microenvironment in immune modulation: Potential targets for intervention",

abstract = "Malignant gliomas are associated with poor prognoses despite surgical, radiation and chemotherapy interventions. Since notable side-effects are associated with each of the aforementioned therapies, the future design of glioma immunotherapy clinical trials will need to address immune modulation at multiple levels for efficacious results. The review discusses emerging data that provides novel insights into immune modulation and their possible implications for immunotherapeutic approaches. The next generation of immunotherapy is largely focused on improving immune effector targeting and directing the tumor immune microenvironment to work synergistically with systematic immune activation.",

keywords = "Antigen presenting cells, Central nervous system, Dendritic cell, Glioblastoma multiforme, Microglia, Regulatory T cell",

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year = "2006",

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T2 - Potential targets for intervention

AU - Dey, Mahua

AU - Hussain, S. Farzana

AU - Heimberger, Amy B.

PY - 2006

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N2 - Malignant gliomas are associated with poor prognoses despite surgical, radiation and chemotherapy interventions. Since notable side-effects are associated with each of the aforementioned therapies, the future design of glioma immunotherapy clinical trials will need to address immune modulation at multiple levels for efficacious results. The review discusses emerging data that provides novel insights into immune modulation and their possible implications for immunotherapeutic approaches. The next generation of immunotherapy is largely focused on improving immune effector targeting and directing the tumor immune microenvironment to work synergistically with systematic immune activation.

AB - Malignant gliomas are associated with poor prognoses despite surgical, radiation and chemotherapy interventions. Since notable side-effects are associated with each of the aforementioned therapies, the future design of glioma immunotherapy clinical trials will need to address immune modulation at multiple levels for efficacious results. The review discusses emerging data that provides novel insights into immune modulation and their possible implications for immunotherapeutic approaches. The next generation of immunotherapy is largely focused on improving immune effector targeting and directing the tumor immune microenvironment to work synergistically with systematic immune activation.

KW - Antigen presenting cells

KW - Central nervous system

KW - Dendritic cell

KW - Glioblastoma multiforme

KW - Microglia

KW - Regulatory T cell

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The role of glioma microenvironment in immune modulation: Potential targets for intervention

Abstract

Keywords

ASJC Scopus subject areas

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