The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients with Treatment-refractory Infections

Francesco P. Tambaro; Dristhi Ragoonanan; Priti Tewari; Demetrios Petropoulos; Fleur M. Aung; Kris M. Mahadeo; Sajad Khazal

doi:10.1097/MPH.0000000000002111

The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients with Treatment-refractory Infections

Francesco P. Tambaro, Dristhi Ragoonanan, Priti Tewari, Demetrios Petropoulos, Fleur M. Aung, Kris M. Mahadeo, Sajad Khazal

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

While advancements in cellular therapy have improved outcomes for patients with refractory leukemia, severe infections may hinder access. Granulocyte transfusions, in combination with anti-microbial therapy, may be a safe option to facilitate candidacy for chimeric antigen receptor T-cell therapy in patients with leukemia and prolonged immune-compromised status.

Original language	English (US)
Pages (from-to)	E463-E466
Journal	Journal of Pediatric Hematology/Oncology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1097/MPH.0000000000002111
State	Published - Mar 1 2022

Keywords

acute lymphoblastic leukemia
chimeric antigen receptor T-cell therapy
granulocyte transfusions

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000002111

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Tambaro, F. P., Ragoonanan, D., Tewari, P., Petropoulos, D., Aung, F. M., Mahadeo, K. M., & Khazal, S. (2022). The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients with Treatment-refractory Infections. Journal of Pediatric Hematology/Oncology, 44(2), E463-E466. https://doi.org/10.1097/MPH.0000000000002111

The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients with Treatment-refractory Infections. / Tambaro, Francesco P.; Ragoonanan, Dristhi ; Tewari, Priti et al.
In: Journal of Pediatric Hematology/Oncology, Vol. 44, No. 2, 01.03.2022, p. E463-E466.

Research output: Contribution to journal › Article › peer-review

Tambaro, FP, Ragoonanan, D , Tewari, P , Petropoulos, D , Aung, FM, Mahadeo, KM & Khazal, S 2022, 'The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients with Treatment-refractory Infections', Journal of Pediatric Hematology/Oncology, vol. 44, no. 2, pp. E463-E466. https://doi.org/10.1097/MPH.0000000000002111

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The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients with Treatment-refractory Infections

Abstract

Keywords

ASJC Scopus subject areas

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