The role of MicroRNA in lung cancer drug resistance and targeted therapy

Zhaohui Gong, Zhuo Dong, Lihua Yang, Jie Yang, Jingqiu Li, Yanping Le, Shaomin Wang, Meng Ye, Hui Kuan Lin

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Lung cancer is one of the most common malignant tumors and is the leading cause of cancer mortality worldwide. However, drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue during the chemotherapy of lung cancer. Many mechanisms such as the changes of drug metabolism related genes and signal pathways are involved in the chemoresistance. MicroRNAs (miRNAs) are a class of endogenetic, non-coding, short-chain and small RNAs that regulate cell growth, apoptosis and signal transduction. miRNA polymorphisms associate with drug metabolism and drug resistance formation. Furthermore, differentially expressed miRNAs play critical roles in prediction of the sensitivity to chemotherapeutic agents in lung cancer. Regulation of specific miRNA expression will break a new path for overcoming lung cancer resistance and the personalized therapy. Together, in this chapter we have discussed the current understanding of the role of miRNA on drug resistance, and the potential implications of miRNA in lung cancer targeted therapy.

Original languageEnglish (US)
Title of host publicationMicroRNA Targeted Cancer Therapy
PublisherSpringer International Publishing
Pages51-82
Number of pages32
ISBN (Electronic)9783319051345
ISBN (Print)3319051334, 9783319051338
DOIs
StatePublished - Feb 1 2014

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'The role of MicroRNA in lung cancer drug resistance and targeted therapy'. Together they form a unique fingerprint.

Cite this