TY - CHAP
T1 - The role of MicroRNA in lung cancer drug resistance and targeted therapy
AU - Gong, Zhaohui
AU - Dong, Zhuo
AU - Yang, Lihua
AU - Yang, Jie
AU - Li, Jingqiu
AU - Le, Yanping
AU - Wang, Shaomin
AU - Ye, Meng
AU - Lin, Hui Kuan
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2014. All rights reserved.
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Lung cancer is one of the most common malignant tumors and is the leading cause of cancer mortality worldwide. However, drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue during the chemotherapy of lung cancer. Many mechanisms such as the changes of drug metabolism related genes and signal pathways are involved in the chemoresistance. MicroRNAs (miRNAs) are a class of endogenetic, non-coding, short-chain and small RNAs that regulate cell growth, apoptosis and signal transduction. miRNA polymorphisms associate with drug metabolism and drug resistance formation. Furthermore, differentially expressed miRNAs play critical roles in prediction of the sensitivity to chemotherapeutic agents in lung cancer. Regulation of specific miRNA expression will break a new path for overcoming lung cancer resistance and the personalized therapy. Together, in this chapter we have discussed the current understanding of the role of miRNA on drug resistance, and the potential implications of miRNA in lung cancer targeted therapy.
AB - Lung cancer is one of the most common malignant tumors and is the leading cause of cancer mortality worldwide. However, drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue during the chemotherapy of lung cancer. Many mechanisms such as the changes of drug metabolism related genes and signal pathways are involved in the chemoresistance. MicroRNAs (miRNAs) are a class of endogenetic, non-coding, short-chain and small RNAs that regulate cell growth, apoptosis and signal transduction. miRNA polymorphisms associate with drug metabolism and drug resistance formation. Furthermore, differentially expressed miRNAs play critical roles in prediction of the sensitivity to chemotherapeutic agents in lung cancer. Regulation of specific miRNA expression will break a new path for overcoming lung cancer resistance and the personalized therapy. Together, in this chapter we have discussed the current understanding of the role of miRNA on drug resistance, and the potential implications of miRNA in lung cancer targeted therapy.
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U2 - 10.1007/978-3-319-05134-5_3
DO - 10.1007/978-3-319-05134-5_3
M3 - Chapter
AN - SCOPUS:84930066718
SN - 3319051334
SN - 9783319051338
SP - 51
EP - 82
BT - MicroRNA Targeted Cancer Therapy
PB - Springer International Publishing
ER -