Abstract
The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.
Original language | English (US) |
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Pages (from-to) | 385-394 |
Number of pages | 10 |
Journal | Journal of neuro-oncology |
Volume | 123 |
Issue number | 3 |
DOIs | |
State | Published - Jul 23 2015 |
Keywords
- Glioblastoma
- Immune suppression
- STAT3
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research