The role of STAT3 in tumor-mediated immune suppression

Sherise D. Ferguson; Visish M. Srinivasan; Amy B. Heimberger

doi:10.1007/s11060-015-1731-3

The role of STAT3 in tumor-mediated immune suppression

Sherise D. Ferguson
, Visish M. Srinivasan
, Amy B. Heimberger

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.

Original language	English (US)
Pages (from-to)	385-394
Number of pages	10
Journal	Journal of neuro-oncology
Volume	123
Issue number	3
DOIs	https://doi.org/10.1007/s11060-015-1731-3
State	Published - Jul 23 2015

Keywords

Glioblastoma
Immune suppression
STAT3

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

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10.1007/s11060-015-1731-3

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title = "The role of STAT3 in tumor-mediated immune suppression",

abstract = "The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.",

keywords = "Glioblastoma, Immune suppression, STAT3",

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AU - Srinivasan, Visish M.

AU - Heimberger, Amy B.

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N2 - The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.

AB - The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.

KW - Glioblastoma

KW - Immune suppression

KW - STAT3

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M3 - Review article

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The role of STAT3 in tumor-mediated immune suppression

Abstract

Keywords

ASJC Scopus subject areas

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