Abstract
Incubation of rat peritoneal mast cells with substance P, or with its N-terminal tetrapeptide segment but not with its C-terminal heptapeptide segment, caused a release of histamine. The half maximal release of histamine was observed with 8 × 10-6 M substance P, while the N-terminal tetrapeptide was significantly less potent. The presence of the two basic amino acids in the N-terminal tetrapeptide was necessary but was not sufficient to account for the full histamine-releasing capacity of substance P. The inhibitory effect of different anti-inflammatory agents on mast cell degranulation caused by substance P and Compound 48/80 was compared.
Original language | English (US) |
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Pages (from-to) | 1025-1027 |
Number of pages | 3 |
Journal | Neuropharmacology |
Volume | 20 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1981 |
ASJC Scopus subject areas
- Pharmacology
- Cellular and Molecular Neuroscience