The role of the N-terminal tetrapeptide in the histamine releasing action of substance P

N. Mazurek, I. Pecht, V. I. Teichberg, S. Btumberg

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Incubation of rat peritoneal mast cells with substance P, or with its N-terminal tetrapeptide segment but not with its C-terminal heptapeptide segment, caused a release of histamine. The half maximal release of histamine was observed with 8 × 10-6 M substance P, while the N-terminal tetrapeptide was significantly less potent. The presence of the two basic amino acids in the N-terminal tetrapeptide was necessary but was not sufficient to account for the full histamine-releasing capacity of substance P. The inhibitory effect of different anti-inflammatory agents on mast cell degranulation caused by substance P and Compound 48/80 was compared.

Original languageEnglish (US)
Pages (from-to)1025-1027
Number of pages3
JournalNeuropharmacology
Volume20
Issue number11
DOIs
StatePublished - Nov 1981

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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