The seven faces of SIRT7

Maximilian F. Blank, Ingrid Grummt

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

SIRT7, a member of the sirtuin family of NAD+-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this important functional link, the enzymatic activity, the molecular targets and physiological functions of SIRT7 are poorly defined. Here, we review recent progress in SIRT7 research and elaborate the main pathways in which SIRT7 participates.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalTranscription
Volume8
Issue number2
DOIs
StatePublished - Mar 15 2017

Fingerprint

Cell proliferation
Cell Cycle Checkpoints
Ribosomes
NAD
Carcinogenesis
Homeostasis
Aging of materials
Cells
Cell Proliferation
Research
Proteins

Keywords

  • SIRT7
  • metabolism
  • stress response
  • transcription
  • tumorigenesis

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

Cite this

The seven faces of SIRT7. / Blank, Maximilian F.; Grummt, Ingrid.

In: Transcription, Vol. 8, No. 2, 15.03.2017, p. 67-74.

Research output: Contribution to journalReview article

Blank, Maximilian F. ; Grummt, Ingrid. / The seven faces of SIRT7. In: Transcription. 2017 ; Vol. 8, No. 2. pp. 67-74.
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