The syntheses, crystal structure, thermal analysis, and anticancer activities of novel dipicolinate complexes

Nazli Uzun; Alper Tolga C¸olak; Fatih Mehmet Emen; Gorkem Kismali; Ogunc Meral; Merve Alpay; Gülbanu Koyundereli C¸ilgi; Ertan Şahin

doi:10.1080/00958972.2014.1003371

The syntheses, crystal structure, thermal analysis, and anticancer activities of novel dipicolinate complexes

Nazli Uzun
, Alper Tolga C¸olak
, Fatih Mehmet Emen
, Gorkem Kismali
, Ogunc Meral
, Merve Alpay
, Gülbanu Koyundereli C¸ilgi
, Ertan Şahin

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

(Figure Presented) [Cu(pydc)(eim)3]·H₂O (1), [Cu(pydc)(4hp)(H₂O)] (2), and [Ni(pydc)(3hp)(H₂O)₂][Cu(pydc)(3hp) (H₂O)₂]·3H₂O (3) (H₂pydc = 2,6-pyridinedicarboxylic acid or dipicolinic acid, eim = 2-ethylimidazole, 4hp = 4-hydroxypyridine, 3hp = 3-hydroxypyridine) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV-vis and IR spectra), and single-crystal X-ray diffraction. Crystal analysis revealed that the complexes extended to 3-D supramolecular networks through intermolecular H-bonding and molecular interactions between the ligand moieties and water molecules. The thermal stabilities of complexes are investigated by thermogravimetry, differential thermogravimetry, and differential thermal analysis techniques. The effects of complexes on the proliferation of HT-1080 fibrosarcoma cells were investigated using the quick cell proliferation assay. The cell viability changes were found to depend on the concentrations and type of complex.

Original language	English (US)
Pages (from-to)	949-967
Number of pages	19
Journal	Journal of Coordination Chemistry
Volume	68
Issue number	6
DOIs	https://doi.org/10.1080/00958972.2014.1003371
State	Published - 2015
Externally published	Yes

Keywords

2,6-Pyridinedicarboxylate
Anticancer activities
Crystal structure
Thermal analysis

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Materials Chemistry

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10.1080/00958972.2014.1003371

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title = "The syntheses, crystal structure, thermal analysis, and anticancer activities of novel dipicolinate complexes",

abstract = "(Figure Presented) [Cu(pydc)(eim)3]·H2O (1), [Cu(pydc)(4hp)(H2O)] (2), and [Ni(pydc)(3hp)(H2O)2][Cu(pydc)(3hp) (H2O)2]·3H2O (3) (H2pydc = 2,6-pyridinedicarboxylic acid or dipicolinic acid, eim = 2-ethylimidazole, 4hp = 4-hydroxypyridine, 3hp = 3-hydroxypyridine) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV-vis and IR spectra), and single-crystal X-ray diffraction. Crystal analysis revealed that the complexes extended to 3-D supramolecular networks through intermolecular H-bonding and molecular interactions between the ligand moieties and water molecules. The thermal stabilities of complexes are investigated by thermogravimetry, differential thermogravimetry, and differential thermal analysis techniques. The effects of complexes on the proliferation of HT-1080 fibrosarcoma cells were investigated using the quick cell proliferation assay. The cell viability changes were found to depend on the concentrations and type of complex.",

keywords = "2,6-Pyridinedicarboxylate, Anticancer activities, Crystal structure, Thermal analysis",

author = "Nazli Uzun and C¸olak, \{Alper Tolga\} and Emen, \{Fatih Mehmet\} and Gorkem Kismali and Ogunc Meral and Merve Alpay and C¸ilgi, \{G{\"u}lbanu Koyundereli\} and Ertan {\c S}ahin",

note = "Publisher Copyright: {\textcopyright} 2015 Taylor \& Francis.",

year = "2015",

doi = "10.1080/00958972.2014.1003371",

language = "English (US)",

volume = "68",

pages = "949--967",

journal = "Journal of Coordination Chemistry",

issn = "0095-8972",

publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - The syntheses, crystal structure, thermal analysis, and anticancer activities of novel dipicolinate complexes

AU - Uzun, Nazli

AU - C¸olak, Alper Tolga

AU - Emen, Fatih Mehmet

AU - Kismali, Gorkem

AU - Meral, Ogunc

AU - Alpay, Merve

AU - C¸ilgi, Gülbanu Koyundereli

AU - Şahin, Ertan

PY - 2015

Y1 - 2015

N2 - (Figure Presented) [Cu(pydc)(eim)3]·H2O (1), [Cu(pydc)(4hp)(H2O)] (2), and [Ni(pydc)(3hp)(H2O)2][Cu(pydc)(3hp) (H2O)2]·3H2O (3) (H2pydc = 2,6-pyridinedicarboxylic acid or dipicolinic acid, eim = 2-ethylimidazole, 4hp = 4-hydroxypyridine, 3hp = 3-hydroxypyridine) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV-vis and IR spectra), and single-crystal X-ray diffraction. Crystal analysis revealed that the complexes extended to 3-D supramolecular networks through intermolecular H-bonding and molecular interactions between the ligand moieties and water molecules. The thermal stabilities of complexes are investigated by thermogravimetry, differential thermogravimetry, and differential thermal analysis techniques. The effects of complexes on the proliferation of HT-1080 fibrosarcoma cells were investigated using the quick cell proliferation assay. The cell viability changes were found to depend on the concentrations and type of complex.

AB - (Figure Presented) [Cu(pydc)(eim)3]·H2O (1), [Cu(pydc)(4hp)(H2O)] (2), and [Ni(pydc)(3hp)(H2O)2][Cu(pydc)(3hp) (H2O)2]·3H2O (3) (H2pydc = 2,6-pyridinedicarboxylic acid or dipicolinic acid, eim = 2-ethylimidazole, 4hp = 4-hydroxypyridine, 3hp = 3-hydroxypyridine) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV-vis and IR spectra), and single-crystal X-ray diffraction. Crystal analysis revealed that the complexes extended to 3-D supramolecular networks through intermolecular H-bonding and molecular interactions between the ligand moieties and water molecules. The thermal stabilities of complexes are investigated by thermogravimetry, differential thermogravimetry, and differential thermal analysis techniques. The effects of complexes on the proliferation of HT-1080 fibrosarcoma cells were investigated using the quick cell proliferation assay. The cell viability changes were found to depend on the concentrations and type of complex.

KW - 2,6-Pyridinedicarboxylate

KW - Anticancer activities

KW - Crystal structure

KW - Thermal analysis

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U2 - 10.1080/00958972.2014.1003371

DO - 10.1080/00958972.2014.1003371

M3 - Article

AN - SCOPUS:84925500587

SN - 0095-8972

VL - 68

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EP - 967

JO - Journal of Coordination Chemistry

JF - Journal of Coordination Chemistry

IS - 6

ER -

The syntheses, crystal structure, thermal analysis, and anticancer activities of novel dipicolinate complexes

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