The time course of cognitive deficits in experimental subarachnoid hemorrhage

Zhiyuan Vera Zheng, Ping Kuen Lam, Wai-sang Poon, Kwok Chu George Wong

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Subarachnoid hemorrhage (SAH) is a devastating stroke type. Approximately 50% of survivors suffer from the permanent disability, caused by the cognitive deficits. To enrich the pre-clinical research on the neurological deficits after SAH, we investigate the temporal cognitive deficits and the longitudinal course of cognitive recovery in endovascular perforation SAH murine model. The SAH mice show reproducible body weakness and headache-symbolized moaning symptoms, which is closed to clinical patients. SAH mice exhibit significantly impaired cognitive function in domains of learning ability, short-term and long-term memory. The cognitive deficits occur mostly in the early phase and recover gradually till day 10 after SAH. The systematical assessments of cognitive function after experimental aneurysmal SAH elucidate the time course of cognitive deficits and provide the time window of potential interventions.

Original languageEnglish (US)
Title of host publicationActa Neurochirurgica, Supplementum
PublisherSpringer-Verlag Wien
Pages121-125
Number of pages5
DOIs
StatePublished - Jan 1 2020

Publication series

NameActa Neurochirurgica, Supplementum
Volume127
ISSN (Print)0065-1419
ISSN (Electronic)2197-8395

Fingerprint

Subarachnoid Hemorrhage
Animal Models
Cognition
Aptitude
Long-Term Memory
Switzerland
Headache
Survivors
Stroke
Learning
Research

Keywords

  • Animal model
  • Cognitive deficits
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Zheng, Z. V., Lam, P. K., Poon, W., & Wong, K. C. G. (2020). The time course of cognitive deficits in experimental subarachnoid hemorrhage. In Acta Neurochirurgica, Supplementum (pp. 121-125). (Acta Neurochirurgica, Supplementum; Vol. 127). Springer-Verlag Wien. https://doi.org/10.1007/978-3-030-04615-6_18

The time course of cognitive deficits in experimental subarachnoid hemorrhage. / Zheng, Zhiyuan Vera; Lam, Ping Kuen; Poon, Wai-sang; Wong, Kwok Chu George.

Acta Neurochirurgica, Supplementum. Springer-Verlag Wien, 2020. p. 121-125 (Acta Neurochirurgica, Supplementum; Vol. 127).

Research output: Chapter in Book/Report/Conference proceedingChapter

Zheng, ZV, Lam, PK, Poon, W & Wong, KCG 2020, The time course of cognitive deficits in experimental subarachnoid hemorrhage. in Acta Neurochirurgica, Supplementum. Acta Neurochirurgica, Supplementum, vol. 127, Springer-Verlag Wien, pp. 121-125. https://doi.org/10.1007/978-3-030-04615-6_18
Zheng ZV, Lam PK, Poon W, Wong KCG. The time course of cognitive deficits in experimental subarachnoid hemorrhage. In Acta Neurochirurgica, Supplementum. Springer-Verlag Wien. 2020. p. 121-125. (Acta Neurochirurgica, Supplementum). https://doi.org/10.1007/978-3-030-04615-6_18
Zheng, Zhiyuan Vera ; Lam, Ping Kuen ; Poon, Wai-sang ; Wong, Kwok Chu George. / The time course of cognitive deficits in experimental subarachnoid hemorrhage. Acta Neurochirurgica, Supplementum. Springer-Verlag Wien, 2020. pp. 121-125 (Acta Neurochirurgica, Supplementum).
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