The tumor immune contexture of salivary duct carcinoma

Gustavo Schvartsman; Diana Bell; Maria Laura Rubin; Michael Tetzlaff; Ehab Hanna; Jiun Kae Jack Lee; Randal Weber; Jack Phan; Bonnie S. Glisson; Renata Ferrarotto

doi:10.1002/hed.26587

The tumor immune contexture of salivary duct carcinoma

Gustavo Schvartsman, Diana Bell, Maria Laura Rubin, Michael Tetzlaff, Ehab Hanna, Jiun Kae Jack Lee, Randal Weber, Jack Phan, Bonnie S. Glisson, Renata Ferrarotto

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy. Recently, biomarker studies found promising targetable alterations. In this study, we provide a descriptive analysis of tumor and immune biomarkers and survival associations. Methods: We extracted clinical data and performed immunohistochemistry for AR, AR-V7, HER-2, PD-L1, LAG-3, and tumor-infiltrating immune cells. Results: We included 17 patients. Age ranged from 42 to 85 years old; HER-2 was overexpressed or amplified in 65%. AR was positive in 88% of patients, while AR-V7 was positive in 13% by IHC. We found low scores of immune infiltration and a PD-L1 expression in 53%. We found no clinically significant association between biomarkers and survival outcomes. Conclusion: In this small series of SDC, biomarkers do not seem to correlate with disease biology, although they provide additional treatment options. SDC may harbor a different immune profile compared to other subtypes, with an indication of T-cell dysfunction.

Original language	English (US)
Pages (from-to)	1213-1219
Number of pages	7
Journal	Head and Neck
Volume	43
Issue number	4
DOIs	https://doi.org/10.1002/hed.26587
State	Published - Apr 2021

Keywords

ErbB-2 receptor
androgen receptor
immunotherapy
salivary gland cancer
tumor microenvironment

ASJC Scopus subject areas

Otorhinolaryngology

MD Anderson CCSG core facilities

Biostatistics Resource Group

Access to Document

10.1002/hed.26587

Cite this

@article{99956a9bc19d43588490985d0f0fb638,

title = "The tumor immune contexture of salivary duct carcinoma",

abstract = "Background: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy. Recently, biomarker studies found promising targetable alterations. In this study, we provide a descriptive analysis of tumor and immune biomarkers and survival associations. Methods: We extracted clinical data and performed immunohistochemistry for AR, AR-V7, HER-2, PD-L1, LAG-3, and tumor-infiltrating immune cells. Results: We included 17 patients. Age ranged from 42 to 85 years old; HER-2 was overexpressed or amplified in 65%. AR was positive in 88% of patients, while AR-V7 was positive in 13% by IHC. We found low scores of immune infiltration and a PD-L1 expression in 53%. We found no clinically significant association between biomarkers and survival outcomes. Conclusion: In this small series of SDC, biomarkers do not seem to correlate with disease biology, although they provide additional treatment options. SDC may harbor a different immune profile compared to other subtypes, with an indication of T-cell dysfunction.",

keywords = "ErbB-2 receptor, androgen receptor, immunotherapy, salivary gland cancer, tumor microenvironment",

author = "Gustavo Schvartsman and Diana Bell and Rubin, {Maria Laura} and Michael Tetzlaff and Ehab Hanna and Lee, {Jiun Kae Jack} and Randal Weber and Jack Phan and Glisson, {Bonnie S.} and Renata Ferrarotto",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

month = apr,

doi = "10.1002/hed.26587",

language = "English (US)",

volume = "43",

pages = "1213--1219",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "4",

}

TY - JOUR

T1 - The tumor immune contexture of salivary duct carcinoma

AU - Schvartsman, Gustavo

AU - Bell, Diana

AU - Rubin, Maria Laura

AU - Tetzlaff, Michael

AU - Hanna, Ehab

AU - Lee, Jiun Kae Jack

AU - Weber, Randal

AU - Phan, Jack

AU - Glisson, Bonnie S.

AU - Ferrarotto, Renata

PY - 2021/4

Y1 - 2021/4

N2 - Background: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy. Recently, biomarker studies found promising targetable alterations. In this study, we provide a descriptive analysis of tumor and immune biomarkers and survival associations. Methods: We extracted clinical data and performed immunohistochemistry for AR, AR-V7, HER-2, PD-L1, LAG-3, and tumor-infiltrating immune cells. Results: We included 17 patients. Age ranged from 42 to 85 years old; HER-2 was overexpressed or amplified in 65%. AR was positive in 88% of patients, while AR-V7 was positive in 13% by IHC. We found low scores of immune infiltration and a PD-L1 expression in 53%. We found no clinically significant association between biomarkers and survival outcomes. Conclusion: In this small series of SDC, biomarkers do not seem to correlate with disease biology, although they provide additional treatment options. SDC may harbor a different immune profile compared to other subtypes, with an indication of T-cell dysfunction.

AB - Background: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy. Recently, biomarker studies found promising targetable alterations. In this study, we provide a descriptive analysis of tumor and immune biomarkers and survival associations. Methods: We extracted clinical data and performed immunohistochemistry for AR, AR-V7, HER-2, PD-L1, LAG-3, and tumor-infiltrating immune cells. Results: We included 17 patients. Age ranged from 42 to 85 years old; HER-2 was overexpressed or amplified in 65%. AR was positive in 88% of patients, while AR-V7 was positive in 13% by IHC. We found low scores of immune infiltration and a PD-L1 expression in 53%. We found no clinically significant association between biomarkers and survival outcomes. Conclusion: In this small series of SDC, biomarkers do not seem to correlate with disease biology, although they provide additional treatment options. SDC may harbor a different immune profile compared to other subtypes, with an indication of T-cell dysfunction.

KW - ErbB-2 receptor

KW - androgen receptor

KW - immunotherapy

KW - salivary gland cancer

KW - tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85100942142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85100942142&partnerID=8YFLogxK

U2 - 10.1002/hed.26587

DO - 10.1002/hed.26587

M3 - Article

C2 - 33576119

AN - SCOPUS:85100942142

SN - 1043-3074

VL - 43

SP - 1213

EP - 1219

JO - Head and Neck

JF - Head and Neck

IS - 4

ER -

The tumor immune contexture of salivary duct carcinoma

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

Other files and links

Fingerprint

Cite this