@article{1c7be4ec92394a3381841f8a87af51f0,
title = "The unfulfilled/DHR51 gene of Drosophila melanogaster modulates wing expansion and fertility",
abstract = "This is the first functional analysis in Drosophila of unfulfilled (unf; DHR51), the NR2E3 nuclear receptor superfamily ortholog of C. elegans fax-1 and human PNR. Both fax-1 and PNR mutations disrupt developmental events in a limited number of neurons, resulting in behavioral or sensory deficits. An analysis of two independent unf alleles revealed that unf mutants are characterized by one of two phenotypes. A proportion of the mutants eclosed but failed to expand their wings and were poorly coordinated. The remainder completed wing expansion but displayed severely compromised fertility. Consistent with the restricted neural expression of fax-1 and PNR, unf expression was detected in situ only in mushroom body neurons and a small number of other cells of the central nervous system (CNS). These data support the hypothesis that the wing expansion failure and the compromised fertility of unf mutants are the result of underlying neural defects.",
keywords = "Behavior, CG16801, Fax-1, Homologous recombination, Mushroom body, NR2E3, Nuclear receptor, PNR, Sterility",
author = "Carl Sung and Wong, {Laura E.} and {Chang Sen}, {Lauren Q.} and Elizabeth Nguyen and Nelson Lazaga and Gavin Ganzer and McNabb, {Susan L.} and Steven Robinow",
note = "Funding Information: We acknowledge the support of ANPCyT , Argentina; YerPhI , Armenia; ARC , Australia; BMWF , Austria; ANAS , Azerbaijan; SSTC , Belarus; CNPq and FAPESP , Brazil; NSERC , NRC and CFI , Canada; CERN ; CONICYT , Chile; CAS , MOST and NSFC , China; COLCIENCIAS , Colombia; MSMT CR , MPO CR and VSC CR , Czech Republic; DNRF , DNSRC and Lundbeck Foundation , Denmark; ARTEMIS , European Union; IN2P3-CNRS , CEA-DSM/IRFU , France; GNAS , Georgia; BMBF , DFG , HGF , MPG and AvH Foundation , Germany; GSRT , Greece; ISF , MINERVA , GIF , DIP and Benoziyo Center , Israel; INFN , Italy; MEXT and JSPS , Japan; CNRST , Morocco; FOM and NWO , Netherlands; RCN , Norway; MNiSW , Poland; GRICES and FCT , Portugal; MERYS (MECTS) , Romania; MES of Russia and ROSATOM , Russian Federation; JINR ; MSTD , Serbia; MSSR , Slovakia; ARRS and MVZT , Slovenia; DST/NRF , South Africa; MICINN , Spain; SRC and Wallenberg Foundation , Sweden; SER , SNSF and Cantons of Bern and Geneva , Switzerland; NSC , Taiwan; TAEK , Turkey; STFC , the Royal Society and Leverhulme Trust , United Kingdom; DOE and NSF , United States of America. ",
year = "2009",
month = jan,
doi = "10.1002/dvdy.21817",
language = "English (US)",
volume = "238",
pages = "171--182",
journal = "Developmental Dynamics",
issn = "1058-8388",
publisher = "Wiley-Liss Inc.",
number = "1",
}