The value of DTI: achieving high diagnostic performance for brain metastasis

Ma Liheng; Xu Guofan; Rosario Francesco Balzano; Liang Yuying; Hong Weifeng; Yang Ning; Ji Yayun; Liu Mouyuan; Giuseppe Guglielmi

doi:10.1007/s11547-020-01243-6

The value of DTI: achieving high diagnostic performance for brain metastasis

Ma Liheng, Xu Guofan, Rosario Francesco Balzano, Liang Yuying, Hong Weifeng, Yang Ning, Ji Yayun, Liu Mouyuan, Giuseppe Guglielmi

Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: The evaluation of brain metastases generally requires post-contrast MRI exam, but some patients have contraindication to contrast medium administration. Purpose: To investigate the value of the MRI diffusion tensor imaging (DTI) for detection of metastatic brain tumor. Materials and methods: We retrospectively analyzed the MRI data from 23 patients (13 males and 10 females) with brain metastases. The MRI protocol consisted in T1WI, T2WI, post-contrast 3DT1WI and DTI images (b = 1000) sequences. The brain metastatic lesions were counted in each of these sequences. We compared the advantages and limitations of different sequences in the brain metastases detection. The number of metastatic lesions identified on the contrast-enhanced 3DT1WI image is used as the reference. FA values were measured in the intratumoral, adjacent peritumoral and distant peritumoral edema area (PTEA) of brain metastasis, and the differences were statistically analyzed. Results: DTI can detect more brain metastatic lesions rather than T1WI and T2WI. The number of brain metastases on DTI is similar to post-contrast 3D T1WI. There is no statistical difference in the FA value change between the adjacent and distant PTEA. Conclusion: The DTI original image can be used as an alternative examination for patients with contraindications to contrast-enhanced MRI. It has high sensitivity to intratumoral hemorrhage, which has advantage to detect brain metastatic lesions as compared with T1WI or T2WI images.

Original language	English (US)
Pages (from-to)	291-298
Number of pages	8
Journal	Radiologia Medica
Volume	126
Issue number	2
DOIs	https://doi.org/10.1007/s11547-020-01243-6
State	Published - Feb 2021

Keywords

Brain metastases
Diffusion tensor imaging (DTI)
Magnetic resonance imaging (MRI)
Post-contrast Imaging

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s11547-020-01243-6

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@article{80e03b3ed03743fcb940400335473698,

title = "The value of DTI: achieving high diagnostic performance for brain metastasis",

abstract = "Background: The evaluation of brain metastases generally requires post-contrast MRI exam, but some patients have contraindication to contrast medium administration. Purpose: To investigate the value of the MRI diffusion tensor imaging (DTI) for detection of metastatic brain tumor. Materials and methods: We retrospectively analyzed the MRI data from 23 patients (13 males and 10 females) with brain metastases. The MRI protocol consisted in T1WI, T2WI, post-contrast 3DT1WI and DTI images (b = 1000) sequences. The brain metastatic lesions were counted in each of these sequences. We compared the advantages and limitations of different sequences in the brain metastases detection. The number of metastatic lesions identified on the contrast-enhanced 3DT1WI image is used as the reference. FA values were measured in the intratumoral, adjacent peritumoral and distant peritumoral edema area (PTEA) of brain metastasis, and the differences were statistically analyzed. Results: DTI can detect more brain metastatic lesions rather than T1WI and T2WI. The number of brain metastases on DTI is similar to post-contrast 3D T1WI. There is no statistical difference in the FA value change between the adjacent and distant PTEA. Conclusion: The DTI original image can be used as an alternative examination for patients with contraindications to contrast-enhanced MRI. It has high sensitivity to intratumoral hemorrhage, which has advantage to detect brain metastatic lesions as compared with T1WI or T2WI images.",

keywords = "Brain metastases, Diffusion tensor imaging (DTI), Magnetic resonance imaging (MRI), Post-contrast Imaging",

author = "Ma Liheng and Xu Guofan and Balzano, {Rosario Francesco} and Liang Yuying and Hong Weifeng and Yang Ning and Ji Yayun and Liu Mouyuan and Giuseppe Guglielmi",

note = "Funding Information: This work was supported by the Department of Science and Technology of Guangdong Province [Applicable Grant or Contract Numbers: No. 2014A020212304]. Publisher Copyright: {\textcopyright} 2020, Italian Society of Medical Radiology.",

year = "2021",

month = feb,

doi = "10.1007/s11547-020-01243-6",

language = "English (US)",

volume = "126",

pages = "291--298",

journal = "Radiologia Medica",

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publisher = "Springer-Verlag Italia",

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TY - JOUR

T1 - The value of DTI

T2 - achieving high diagnostic performance for brain metastasis

AU - Liheng, Ma

AU - Guofan, Xu

AU - Balzano, Rosario Francesco

AU - Yuying, Liang

AU - Weifeng, Hong

AU - Ning, Yang

AU - Yayun, Ji

AU - Mouyuan, Liu

AU - Guglielmi, Giuseppe

N1 - Funding Information: This work was supported by the Department of Science and Technology of Guangdong Province [Applicable Grant or Contract Numbers: No. 2014A020212304]. Publisher Copyright: © 2020, Italian Society of Medical Radiology.

PY - 2021/2

Y1 - 2021/2

N2 - Background: The evaluation of brain metastases generally requires post-contrast MRI exam, but some patients have contraindication to contrast medium administration. Purpose: To investigate the value of the MRI diffusion tensor imaging (DTI) for detection of metastatic brain tumor. Materials and methods: We retrospectively analyzed the MRI data from 23 patients (13 males and 10 females) with brain metastases. The MRI protocol consisted in T1WI, T2WI, post-contrast 3DT1WI and DTI images (b = 1000) sequences. The brain metastatic lesions were counted in each of these sequences. We compared the advantages and limitations of different sequences in the brain metastases detection. The number of metastatic lesions identified on the contrast-enhanced 3DT1WI image is used as the reference. FA values were measured in the intratumoral, adjacent peritumoral and distant peritumoral edema area (PTEA) of brain metastasis, and the differences were statistically analyzed. Results: DTI can detect more brain metastatic lesions rather than T1WI and T2WI. The number of brain metastases on DTI is similar to post-contrast 3D T1WI. There is no statistical difference in the FA value change between the adjacent and distant PTEA. Conclusion: The DTI original image can be used as an alternative examination for patients with contraindications to contrast-enhanced MRI. It has high sensitivity to intratumoral hemorrhage, which has advantage to detect brain metastatic lesions as compared with T1WI or T2WI images.

AB - Background: The evaluation of brain metastases generally requires post-contrast MRI exam, but some patients have contraindication to contrast medium administration. Purpose: To investigate the value of the MRI diffusion tensor imaging (DTI) for detection of metastatic brain tumor. Materials and methods: We retrospectively analyzed the MRI data from 23 patients (13 males and 10 females) with brain metastases. The MRI protocol consisted in T1WI, T2WI, post-contrast 3DT1WI and DTI images (b = 1000) sequences. The brain metastatic lesions were counted in each of these sequences. We compared the advantages and limitations of different sequences in the brain metastases detection. The number of metastatic lesions identified on the contrast-enhanced 3DT1WI image is used as the reference. FA values were measured in the intratumoral, adjacent peritumoral and distant peritumoral edema area (PTEA) of brain metastasis, and the differences were statistically analyzed. Results: DTI can detect more brain metastatic lesions rather than T1WI and T2WI. The number of brain metastases on DTI is similar to post-contrast 3D T1WI. There is no statistical difference in the FA value change between the adjacent and distant PTEA. Conclusion: The DTI original image can be used as an alternative examination for patients with contraindications to contrast-enhanced MRI. It has high sensitivity to intratumoral hemorrhage, which has advantage to detect brain metastatic lesions as compared with T1WI or T2WI images.

KW - Brain metastases

KW - Diffusion tensor imaging (DTI)

KW - Magnetic resonance imaging (MRI)

KW - Post-contrast Imaging

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DO - 10.1007/s11547-020-01243-6

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SN - 0033-8362

VL - 126

SP - 291

EP - 298

JO - Radiologia Medica

JF - Radiologia Medica

IS - 2

ER -

The value of DTI: achieving high diagnostic performance for brain metastasis

Abstract

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