The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma

Antonio Herrera-Merchan; Marta Cuadros; Maria Isabel Rodriguez; Sandra Rodriguez; Raul Torres; Marcos Estecio; Isabel F. Coira; Claudia Loidi; Monica Saiz; Pedro Carmona-Saez; Pedro P. Medina

The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma

Antonio Herrera-Merchan, Marta Cuadros, Maria Isabel Rodriguez, Sandra Rodriguez, Raul Torres, Marcos Estecio, Isabel F. Coira, Claudia Loidi, Monica Saiz, Pedro Carmona-Saez, Pedro P. Medina

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers.

Original language	English (US)
Pages (from-to)	1172-1185
Number of pages	14
Journal	Oncotarget
Volume	11
Issue number	13
State	Published - Mar 31 2020

Keywords

FENDRR
FOXF1
LncRNA
Lung cancer
Methylation

ASJC Scopus subject areas

Oncology

MD Anderson CCSG core facilities

Epigenomics Profiling Core Facility

Cite this

@article{463a71ed097d469493eaccd6861eaeaf,

title = "The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma",

abstract = "It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers.",

keywords = "FENDRR, FOXF1, LncRNA, Lung cancer, Methylation",

author = "Antonio Herrera-Merchan and Marta Cuadros and Rodriguez, {Maria Isabel} and Sandra Rodriguez and Raul Torres and Marcos Estecio and Coira, {Isabel F.} and Claudia Loidi and Monica Saiz and Pedro Carmona-Saez and Medina, {Pedro P.}",

note = "Funding Information: PM's lab is funded by the Ministry of Economy of Spain (SAF2015-67919-R), Junta de Andaluc?a (P12-BIO-1655), the Deutsche Jos? Carreras Leuk?mie-Stiftung, BBVA Foundation and Eduardo-Gallego Grant 2015 from Francisco Cobos Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} Herrera-Merchan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2020",

month = mar,

day = "31",

language = "English (US)",

volume = "11",

pages = "1172--1185",

journal = "Oncotarget",

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TY - JOUR

T1 - The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma

AU - Herrera-Merchan, Antonio

AU - Cuadros, Marta

AU - Rodriguez, Maria Isabel

AU - Rodriguez, Sandra

AU - Torres, Raul

AU - Estecio, Marcos

AU - Coira, Isabel F.

AU - Loidi, Claudia

AU - Saiz, Monica

AU - Carmona-Saez, Pedro

AU - Medina, Pedro P.

N1 - Funding Information: PM's lab is funded by the Ministry of Economy of Spain (SAF2015-67919-R), Junta de Andaluc?a (P12-BIO-1655), the Deutsche Jos? Carreras Leuk?mie-Stiftung, BBVA Foundation and Eduardo-Gallego Grant 2015 from Francisco Cobos Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © Herrera-Merchan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2020/3/31

Y1 - 2020/3/31

N2 - It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers.

AB - It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers.

KW - FENDRR

KW - FOXF1

KW - LncRNA

KW - Lung cancer

KW - Methylation

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M3 - Article

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SN - 1949-2553

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JO - Oncotarget

JF - Oncotarget

IS - 13

ER -

The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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