TY - JOUR
T1 - The value of thallium and three-phase bone scans in the evaluation of bone and soft tissue sarcomas
AU - Caluser, Calin I.
AU - Abdel-Dayem, Hussein M.
AU - Macapinlac, Homer A.
AU - Scott, Andrew
AU - Healey, John H.
AU - Huvos, Andrew
AU - Kalaigian, Hovanes
AU - Yeh, Samuel D.J.
AU - Larson, Steven M.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1994/11
Y1 - 1994/11
N2 - Thirty-seven patients with newly diagnosed or treated sarcomas had 47 sets of sequential thallium scans (TS) followed by three-phase bone scan (TPBS) on the same day. The diagnosis in all patients was verified by biopsy (n=40) or long-term follow-up studies (n=7). The sensitivity, specificity, and accuracy of TS and TPBS in detecting sarcomatous lesions was calculated: TS sensitivity was 88%, specificity 69%, and accuracy 83%; blood flow (BF) and blood pool (BP) sensitivity was 91%, specificity 54%, and accuracy 81 %; delayed bone scan (DB) sensitivity was 88%, specificity 38%, and accuracy 74%. In 17 studies the flow and blood pool parts of the TPBS and TS demonstrated the soft tissue component of sarcomas, which would have been missed if only the delayed bone scan had been performed. The TS lesion to normal tissue ratio alone was not very helpful in differentiating sarcomas from benign conditions because some benign lesions are highly cellular and vascular while some malignant lesions, such as chondrosarcoma, have poor vascularity and a less cellular chondroid matrix. However, when the thallium ratio was correlated with similar ratios calculated from yhe BP image, it was found that if the TS lesion to normal tissue ratio exceeded the BP lesion to normal tissue ratio (12 patients), the specificity for detecting sarcomatous lesions was 100%. Nevertheless, the reverse was not true. The positive predictive value of this observation was 100% and the negative predictive value was 37%.
AB - Thirty-seven patients with newly diagnosed or treated sarcomas had 47 sets of sequential thallium scans (TS) followed by three-phase bone scan (TPBS) on the same day. The diagnosis in all patients was verified by biopsy (n=40) or long-term follow-up studies (n=7). The sensitivity, specificity, and accuracy of TS and TPBS in detecting sarcomatous lesions was calculated: TS sensitivity was 88%, specificity 69%, and accuracy 83%; blood flow (BF) and blood pool (BP) sensitivity was 91%, specificity 54%, and accuracy 81 %; delayed bone scan (DB) sensitivity was 88%, specificity 38%, and accuracy 74%. In 17 studies the flow and blood pool parts of the TPBS and TS demonstrated the soft tissue component of sarcomas, which would have been missed if only the delayed bone scan had been performed. The TS lesion to normal tissue ratio alone was not very helpful in differentiating sarcomas from benign conditions because some benign lesions are highly cellular and vascular while some malignant lesions, such as chondrosarcoma, have poor vascularity and a less cellular chondroid matrix. However, when the thallium ratio was correlated with similar ratios calculated from yhe BP image, it was found that if the TS lesion to normal tissue ratio exceeded the BP lesion to normal tissue ratio (12 patients), the specificity for detecting sarcomatous lesions was 100%. Nevertheless, the reverse was not true. The positive predictive value of this observation was 100% and the negative predictive value was 37%.
KW - Bone scan
KW - Soft tissue sarcoma
KW - Thallium-201 chloride
UR - http://www.scopus.com/inward/record.url?scp=0028046046&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028046046&partnerID=8YFLogxK
U2 - 10.1007/BF00182353
DO - 10.1007/BF00182353
M3 - Article
C2 - 7859771
AN - SCOPUS:0028046046
SN - 0340-6997
VL - 21
SP - 1198
EP - 1205
JO - European Journal of Nuclear Medicine
JF - European Journal of Nuclear Medicine
IS - 11
ER -