TY - JOUR
T1 - The zebrafish as a model for gastrointestinal tract–microbe interactions
AU - Flores, Erika M.
AU - Nguyen, Anh T.
AU - Odem, Max A.
AU - Eisenhoffer, George T.
AU - Krachler, Anne Marie
N1 - Funding Information:
We thank members of the Krachler and Eisenhoffer labs for useful comments on earlier versions of the manuscript. We thank Jordan Pietz (University of Texas MD Anderson Cancer Center) for designing Figure. We would like to apologise to everyone whose work we could not include it the current version of the review due to space limitations.
Funding Information:
This work was supported by the National Institutes of Health, National Institute of Allergy and Infectious Diseases (Grant R01 AI132354‐01A1) to A.M.K. and a Diversity Supplement supporting E.F. (3R01AI132354‐02S1); a John S. Dunn Foundation Grant supports M.A.O.; a Molecular Basis of Infectious Disease Fellowship supports A.T.N., and the Cancer Prevention Institute of Texas, RR14007, National Institutes of General Medical Sciences, R01GM124043, and the Linda and Mark Quick Award for Basic Science support G.T.E.
Publisher Copyright:
© 2019 John Wiley & Sons Ltd
PY - 2020/3/1
Y1 - 2020/3/1
N2 - The zebrafish (Danio rerio) has become a widely used vertebrate model for bacterial, fungal, viral, and protozoan infections. Due to its genetic tractability, large clutch sizes, ease of manipulation, and optical transparency during early life stages, it is a particularly useful model to address questions about the cellular microbiology of host–microbe interactions. Although its use as a model for systemic infections, as well as infections localised to the hindbrain and swimbladder having been thoroughly reviewed, studies focusing on host–microbe interactions in the zebrafish gastrointestinal tract have been neglected. Here, we summarise recent findings regarding the developmental and immune biology of the gastrointestinal tract, drawing parallels to mammalian systems. We discuss the use of adult and larval zebrafish as models for gastrointestinal infections, and more generally, for studies of host–microbe interactions in the gut.
AB - The zebrafish (Danio rerio) has become a widely used vertebrate model for bacterial, fungal, viral, and protozoan infections. Due to its genetic tractability, large clutch sizes, ease of manipulation, and optical transparency during early life stages, it is a particularly useful model to address questions about the cellular microbiology of host–microbe interactions. Although its use as a model for systemic infections, as well as infections localised to the hindbrain and swimbladder having been thoroughly reviewed, studies focusing on host–microbe interactions in the zebrafish gastrointestinal tract have been neglected. Here, we summarise recent findings regarding the developmental and immune biology of the gastrointestinal tract, drawing parallels to mammalian systems. We discuss the use of adult and larval zebrafish as models for gastrointestinal infections, and more generally, for studies of host–microbe interactions in the gut.
KW - Danio rerio
KW - gastrointestinal tract
KW - host–pathogen interactions
KW - infection model
KW - microbiome
KW - microbiota
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85077844445&partnerID=8YFLogxK
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U2 - 10.1111/cmi.13152
DO - 10.1111/cmi.13152
M3 - Review article
C2 - 31872937
AN - SCOPUS:85077844445
SN - 1462-5814
VL - 22
JO - Cellular Microbiology
JF - Cellular Microbiology
IS - 3
M1 - e13152
ER -