Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer

David J. McConkey; Woonyoung Choi; Andrea Ochoa; Arlene Siefker-Radtke; Bogdan Czerniak; Colin P.N. Dinney

doi:10.1016/j.hoc.2014.11.003

Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer

David J. McConkey, Woonyoung Choi, Andrea Ochoa, Arlene Siefker-Radtke, Bogdan Czerniak, Colin P.N. Dinney

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Recent studies revealed that muscle-invasive bladder cancers segregate into intrinsic basal and luminal subtypes that are similar to those described for breast cancer. Each subtype is enriched with potentially clinically actionable genomic alterations and epigenetic signatures; there are associations between tumor subtype and sensitivity to conventional cisplatin-based chemotherapy. The authors review biological and clinical characteristics of the intrinsic subtypes and describe their implications for the development of conventional and targeted agents. The role that tumor plasticity seems to play in basal and luminal bladder cancer biology and its potential effects on the development of therapeutic resistance is also discussed.

Original language	English (US)
Pages (from-to)	377-394
Number of pages	18
Journal	Hematology/Oncology Clinics of North America
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.hoc.2014.11.003
State	Published - 2015

Keywords

Basal and luminal
Neoadjuvant chemotherapy
Urothelial cancer

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2014.11.003

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title = "Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer",

abstract = "Recent studies revealed that muscle-invasive bladder cancers segregate into intrinsic basal and luminal subtypes that are similar to those described for breast cancer. Each subtype is enriched with potentially clinically actionable genomic alterations and epigenetic signatures; there are associations between tumor subtype and sensitivity to conventional cisplatin-based chemotherapy. The authors review biological and clinical characteristics of the intrinsic subtypes and describe their implications for the development of conventional and targeted agents. The role that tumor plasticity seems to play in basal and luminal bladder cancer biology and its potential effects on the development of therapeutic resistance is also discussed.",

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AU - Czerniak, Bogdan

AU - Dinney, Colin P.N.

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AB - Recent studies revealed that muscle-invasive bladder cancers segregate into intrinsic basal and luminal subtypes that are similar to those described for breast cancer. Each subtype is enriched with potentially clinically actionable genomic alterations and epigenetic signatures; there are associations between tumor subtype and sensitivity to conventional cisplatin-based chemotherapy. The authors review biological and clinical characteristics of the intrinsic subtypes and describe their implications for the development of conventional and targeted agents. The role that tumor plasticity seems to play in basal and luminal bladder cancer biology and its potential effects on the development of therapeutic resistance is also discussed.

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Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer

Abstract

Keywords

ASJC Scopus subject areas

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