Therapeutic potential of the miRNA–ATM axis in the management of tumor radioresistance

Abdol Hossein Rezaeian; Hashem Khanbabaei; George A. Calin

doi:10.1158/0008-5472.CAN-19-1807

Therapeutic potential of the miRNA–ATM axis in the management of tumor radioresistance

Abdol Hossein Rezaeian, Hashem Khanbabaei, George A. Calin

Translational Molecular Pathology

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its function as a chief mobilizer of the DNA damage response (DDR) upon DNA double-strand breaks. ATM orchestrates the DDR by modulating the expression of various miRNAs through several mechanisms. On the other hand, a set of miRNAs contribute to tight regulation of ATM by directly targeting the 3^'-untranslated region of ATM mRNA. This review addresses the therapeutic application and molecular mechanisms that underlie the intricate interactions between miRNAs and ATM. It also describes therapeutic delivery of miRNAs in different environments such as hypoxic tumor microenvironments.

Original language	English (US)
Pages (from-to)	139-150
Number of pages	12
Journal	Cancer Research
Volume	80
Issue number	2
DOIs	https://doi.org/10.1158/0008-5472.CAN-19-1807
State	Published - 2020

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/0008-5472.CAN-19-1807

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title = "Therapeutic potential of the miRNA–ATM axis in the management of tumor radioresistance",

abstract = "The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its function as a chief mobilizer of the DNA damage response (DDR) upon DNA double-strand breaks. ATM orchestrates the DDR by modulating the expression of various miRNAs through several mechanisms. On the other hand, a set of miRNAs contribute to tight regulation of ATM by directly targeting the 3'-untranslated region of ATM mRNA. This review addresses the therapeutic application and molecular mechanisms that underlie the intricate interactions between miRNAs and ATM. It also describes therapeutic delivery of miRNAs in different environments such as hypoxic tumor microenvironments.",

author = "Rezaeian, {Abdol Hossein} and Hashem Khanbabaei and Calin, {George A.}",

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AU - Khanbabaei, Hashem

AU - Calin, George A.

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N2 - The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its function as a chief mobilizer of the DNA damage response (DDR) upon DNA double-strand breaks. ATM orchestrates the DDR by modulating the expression of various miRNAs through several mechanisms. On the other hand, a set of miRNAs contribute to tight regulation of ATM by directly targeting the 3'-untranslated region of ATM mRNA. This review addresses the therapeutic application and molecular mechanisms that underlie the intricate interactions between miRNAs and ATM. It also describes therapeutic delivery of miRNAs in different environments such as hypoxic tumor microenvironments.

AB - The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its function as a chief mobilizer of the DNA damage response (DDR) upon DNA double-strand breaks. ATM orchestrates the DDR by modulating the expression of various miRNAs through several mechanisms. On the other hand, a set of miRNAs contribute to tight regulation of ATM by directly targeting the 3'-untranslated region of ATM mRNA. This review addresses the therapeutic application and molecular mechanisms that underlie the intricate interactions between miRNAs and ATM. It also describes therapeutic delivery of miRNAs in different environments such as hypoxic tumor microenvironments.

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Therapeutic potential of the miRNA–ATM axis in the management of tumor radioresistance

Abstract

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