Therapy of endocrine disease: Treatment of malignant pheochromocytoma and paraganglioma

Eric Baudin; Mouhammed Amir Habra; Frederic Deschamps; Gilbert Cote; Frederic Dumont; Maria Cabanillas; J. Arfi-Roufe; A. Berdelou; Bryan Moon; Abir Al Ghuzlan; Shreyaskumar Patel; Sophie Leboulleux; Camilo Jimenez

doi:10.1530/EJE-14-0113

Therapy of endocrine disease: Treatment of malignant pheochromocytoma and paraganglioma

Eric Baudin, Mouhammed Amir Habra, Frederic Deschamps, Gilbert Cote, Frederic Dumont, Maria Cabanillas, J. Arfi-Roufe, A. Berdelou, Bryan Moon, Abir Al Ghuzlan, Shreyaskumar Patel, Sophie Leboulleux, Camilo Jimenez

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicianswith three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor growth is the main therapeutic objective in MPP patients. A significant number of MPP patients still die from uncontrolled hormone secretion. In addition, the management of MPPs remains palliative. Steps forward include proper characterization of MPP patients at large cancer referral centerswithmultidisciplinary teams; improved strategies to stratify patients prognostically; and implementation of trials within national and international networks. Progress in the molecular characterization and staging of MPPs constitutes the basis for significant treatment breakthroughs.

Original language	English (US)
Pages (from-to)	R111-R122
Journal	European journal of endocrinology
Volume	171
Issue number	3
DOIs	https://doi.org/10.1530/EJE-14-0113
State	Published - Sep 1 2014

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "Therapy of endocrine disease: Treatment of malignant pheochromocytoma and paraganglioma",

abstract = "Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicianswith three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor growth is the main therapeutic objective in MPP patients. A significant number of MPP patients still die from uncontrolled hormone secretion. In addition, the management of MPPs remains palliative. Steps forward include proper characterization of MPP patients at large cancer referral centerswithmultidisciplinary teams; improved strategies to stratify patients prognostically; and implementation of trials within national and international networks. Progress in the molecular characterization and staging of MPPs constitutes the basis for significant treatment breakthroughs.",

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AU - Baudin, Eric

AU - Habra, Mouhammed Amir

AU - Deschamps, Frederic

AU - Cote, Gilbert

AU - Dumont, Frederic

AU - Cabanillas, Maria

AU - Arfi-Roufe, J.

AU - Berdelou, A.

AU - Moon, Bryan

AU - Ghuzlan, Abir Al

AU - Patel, Shreyaskumar

AU - Leboulleux, Sophie

AU - Jimenez, Camilo

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AB - Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicianswith three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor growth is the main therapeutic objective in MPP patients. A significant number of MPP patients still die from uncontrolled hormone secretion. In addition, the management of MPPs remains palliative. Steps forward include proper characterization of MPP patients at large cancer referral centerswithmultidisciplinary teams; improved strategies to stratify patients prognostically; and implementation of trials within national and international networks. Progress in the molecular characterization and staging of MPPs constitutes the basis for significant treatment breakthroughs.

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Therapy of endocrine disease: Treatment of malignant pheochromocytoma and paraganglioma

Abstract

ASJC Scopus subject areas

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