Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines

Isaiah J Fidler

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

Mice of two different strains were injected subcutaneously with spontaneously metastasizing syngeneic melanomas. After 4 to 6 weeks, the local tumors were removed and, 3 days after surgery, treatment of the metastases was initiated. The treatment consisted of intravenous injections of liposomes containing lymphokines or control supernatant fluids. Liposomes were injected twice weekly for 3 weeks, and the mice were killed 2 weeks later. Seventy-three percent of the mice injected with liposomes containing lymphokines were free of metastases, whereas only 10 percent of the mice treated with control liposomes were tumor-free. These experiments suggest that this form of therapy may provide a valuable addition to the more conventional approaches to the eradication of cancer metastases.

Original languageEnglish (US)
Pages (from-to)1469-1471
Number of pages3
JournalScience
Volume208
Issue number4451
DOIs
StatePublished - Jan 1 1980

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