Abstract
Objectives: In the 2008 World Health Organization classification, cases of acute myeloid leukemia (AML) and myelodysplastic syndrome that arise after chemotherapy or radiation therapy for a primary neoplasm are considered together as therapy-related myeloid neoplasms (TR-MNs). This concept, however, is not universally accepted since there are confounding variables in attributing myeloid neoplasms to earlier therapies. Methods: Cases in session 6 of the 2013 Workshop of the Society for Hematopathology/European Association for Haematopathology illustrated myeloid neoplasms thought likely to be TR-MNs, and discussed the differences and biologic similarities with de novo myeloid neoplasms. Results: We reviewed data showing that diagnosis of TR-MN alters patient outcome only in specific subsets. The session also included examples of therapy-related AML with recurrent genetic abnormalities, such as t(15;17), inv(16), and t(8;21), and reports were highlighted showing that patients with these neoplasms have clinical outcomes similar to patients with their de novo counterparts. Conclusions: The study of TR-MNs will likely provide insight into the pathogenesis of de novo myeloid disease and may explain why some patients with cancer develop TR-MN and evidently have a higher genetic susceptibility, whereas most patients treated with the same agents do not. These studies will also result in critical reappraisal of current concepts related to TR-MNs.
Original language | English (US) |
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Pages (from-to) | 207-218 |
Number of pages | 12 |
Journal | American journal of clinical pathology |
Volume | 144 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2015 |
Keywords
- Alkylating agents
- Ionizing radiation therapy
- Therapy-related acute myeloid leukemia
- Therapy-related myelodysplastic syndrome
- Therapy-related myeloid neoplasms
- Topoisomerase II inhibitors
ASJC Scopus subject areas
- Pathology and Forensic Medicine