TY - JOUR
T1 - Timing of Pancreatic Resection and Patient Outcomes
T2 - Is There a Difference?
AU - Vreeland, Timothy J.
AU - Katz, Mathew H.G.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/2
Y1 - 2018/2
N2 - Rates of long-term survival after treatment of pancreatic cancer remain low, in part because most patients are still treated with primary resection. This approach is often inadequate because of early local control failures, early manifestation of metastatic disease because of the unrecognized and untreated systemic component of this disease, and because half of patients never receive multimodal therapy. Preoperative therapy can be used to improve local control and treat the systemic nature of pancreatic cancer while also selecting for patients who benefit from a morbid operation. Preoperative therapy makes sense for most patients with this aggressive and deadly disease.
AB - Rates of long-term survival after treatment of pancreatic cancer remain low, in part because most patients are still treated with primary resection. This approach is often inadequate because of early local control failures, early manifestation of metastatic disease because of the unrecognized and untreated systemic component of this disease, and because half of patients never receive multimodal therapy. Preoperative therapy can be used to improve local control and treat the systemic nature of pancreatic cancer while also selecting for patients who benefit from a morbid operation. Preoperative therapy makes sense for most patients with this aggressive and deadly disease.
KW - Pancreatic ductal adenocarcinoma
KW - Potentially curable pancreatic cancer
KW - Preoperative therapy
KW - Primary resection
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U2 - 10.1016/j.suc.2017.09.006
DO - 10.1016/j.suc.2017.09.006
M3 - Review article
C2 - 29191278
AN - SCOPUS:85035129433
SN - 0039-6109
VL - 98
SP - 57
EP - 71
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 1
ER -