Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population

Yuan Chin Amy Lee, Shuang Li, Yuji Chen, Qian Li, Chien Jen Chen, Wan Lun Hsu, Pei Jen Lou, Cairong Zhu, Jian Pan, Hongbing Shen, Hongxia Ma, Lin Cai, Baochang He, Yu Wang, Xiaoyan Zhou, Qinghai Ji, Baosen Zhou, Wei Wu, Jie Ma, Paolo BoffettaZuo Feng Zhang, Min Dai, Mia Hashibe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. Results: Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. Conclusions: Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S. populations.

Original languageEnglish (US)
Pages (from-to)92-102
Number of pages11
JournalHead and Neck
Volume41
Issue number1
DOIs
StatePublished - Jan 2019

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Mastication
Head and Neck Neoplasms
Alcohol Drinking
Smoking
Alcohols
Tobacco
Population
Odds Ratio
Far East
Mouth Neoplasms
Mouth
Case-Control Studies
China
Logistic Models
Confidence Intervals
Incidence

Keywords

  • alcohol drinking
  • attributable fraction, head and neck cancer risk
  • betel quid chewing
  • tobacco smoking

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population. / Lee, Yuan Chin Amy; Li, Shuang; Chen, Yuji; Li, Qian; Chen, Chien Jen; Hsu, Wan Lun; Lou, Pei Jen; Zhu, Cairong; Pan, Jian; Shen, Hongbing; Ma, Hongxia; Cai, Lin; He, Baochang; Wang, Yu; Zhou, Xiaoyan; Ji, Qinghai; Zhou, Baosen; Wu, Wei; Ma, Jie; Boffetta, Paolo; Zhang, Zuo Feng; Dai, Min; Hashibe, Mia.

In: Head and Neck, Vol. 41, No. 1, 01.2019, p. 92-102.

Research output: Contribution to journalArticle

Lee, YCA, Li, S, Chen, Y, Li, Q, Chen, CJ, Hsu, WL, Lou, PJ, Zhu, C, Pan, J, Shen, H, Ma, H, Cai, L, He, B, Wang, Y, Zhou, X, Ji, Q, Zhou, B, Wu, W, Ma, J, Boffetta, P, Zhang, ZF, Dai, M & Hashibe, M 2019, 'Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population', Head and Neck, vol. 41, no. 1, pp. 92-102. https://doi.org/10.1002/hed.25383
Lee, Yuan Chin Amy ; Li, Shuang ; Chen, Yuji ; Li, Qian ; Chen, Chien Jen ; Hsu, Wan Lun ; Lou, Pei Jen ; Zhu, Cairong ; Pan, Jian ; Shen, Hongbing ; Ma, Hongxia ; Cai, Lin ; He, Baochang ; Wang, Yu ; Zhou, Xiaoyan ; Ji, Qinghai ; Zhou, Baosen ; Wu, Wei ; Ma, Jie ; Boffetta, Paolo ; Zhang, Zuo Feng ; Dai, Min ; Hashibe, Mia. / Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population. In: Head and Neck. 2019 ; Vol. 41, No. 1. pp. 92-102.
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abstract = "Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95{\%} confidence interval (CI) were estimated using logistic regression. Results: Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2{\%}. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2{\%}). Betel quid chewing alone accounted for 28.7{\%} of head and neck cancer. Conclusions: Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S. populations.",
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AU - Li, Shuang

AU - Chen, Yuji

AU - Li, Qian

AU - Chen, Chien Jen

AU - Hsu, Wan Lun

AU - Lou, Pei Jen

AU - Zhu, Cairong

AU - Pan, Jian

AU - Shen, Hongbing

AU - Ma, Hongxia

AU - Cai, Lin

AU - He, Baochang

AU - Wang, Yu

AU - Zhou, Xiaoyan

AU - Ji, Qinghai

AU - Zhou, Baosen

AU - Wu, Wei

AU - Ma, Jie

AU - Boffetta, Paolo

AU - Zhang, Zuo Feng

AU - Dai, Min

AU - Hashibe, Mia

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N2 - Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. Results: Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. Conclusions: Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S. populations.

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