Topical application of AT1 receptor antagonists prevents medial and neointimal proliferation after balloon injury

J. Taguchi, J. Abe, M. Ohno, S. M. Schwartz, K. Kurokawa

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Angiotensin II plays an important role in neointima formation after vascular injury. A rat model of carotid artery injury was used i) to investigate the effect of single topical application of angiotensin II subtype 1 (AT1) receptor antagonists (CV11974, DuP753) in suppressing medial proliferation at day 2 and neointimal proliferation at day 14, and ii) to investigate the antiproliferative effects of additional application of L-arginine (a nitric oxide precursor). Drugs mixed in 25% (W/W) solutions of F127 pluronic gel were applied topically to injured vessels. Early medial proliferation of smooth muscle cells, assessed by the S-bromo-2'-deoxyuridine labelling index, was significantly suppressed by application of CV11974 (5 mg/kg), 7.5% ± 2.2% vs. 19% ± 3.9% in the control group. The intima/media ratio following CV11974 (10 mg/kg) or DuP753 (12.5 mg/kg) at day 14 was significantly lower than that in the control group (42% ± 7%, 43% ± 14%, and 123% ± 11%, respectively). Additional application of L-arginine seemed to increase effectiveness, but was not statistically significant. In conclusion, single topical application of AT1 receptor antagonists was effective in suppressing early medial proliferation and neointima formation after balloon injury, suggesting that they may be clinically useful after angioplasty or vascular surgery.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalBlood Pressure, Supplement
Volume3
Issue number5
StatePublished - 1994
Externally publishedYes

Keywords

  • CV11974
  • DuP753
  • F127 pluronic gel
  • L-arginine
  • Neointima
  • Single topical application

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Topical application of AT1 receptor antagonists prevents medial and neointimal proliferation after balloon injury'. Together they form a unique fingerprint.

Cite this