Toward targeted fullerene cancer therapy: Design and synthesis of a Paclitaxel-C60-Antibody conjugate

Tatiana Zakharian; Jared Ashcroft; Andrey Mirakyan; Dmitry Tsyboulski; Nancy Benedict; Bruce Weisman; Lon J. Wilson; John W. Marks; Michael R. Rosenblum

Toward targeted fullerene cancer therapy: Design and synthesis of a Paclitaxel-C₆₀-Antibody conjugate

Tatiana Zakharian, Jared Ashcroft, Andrey Mirakyan, Dmitry Tsyboulski, Nancy Benedict, Bruce Weisman, Lon J. Wilson, John W. Marks, Michael R. Rosenblum

Experimental Therapeutics

Research output: Contribution to conference › Paper › peer-review

Abstract

Paclitaxel (Taxol) has been successfully used for treating various types of cancers. A Paclitaxel-C₆₀ conjugate has been synthesized as a derivative of Paclitaxel designed to modify the drug delivery rate. In addition, the Paclitaxel-C₆₀ conjugate is being developed for targeted immunotherapy using antibodies. Toward this purpose, a synthetic route has also been developed to covalently couple C₆₀ and its derivatives to the murine anti-gp 240 antibody, which targets melanoma cells. Triplet-triplet absorption spectroscopy of the C₆₀ chromophore is being explored as a method to characterize and trace C₆₀-antibody conjugates in vitro. Current progress toward the synthesis and characterization of a Paclitaxel-C₆₀-Antibody conjugate is reported.

Original language	English (US)
Pages	338-348
Number of pages	11
State	Published - 2004
Event	ECS Annual Spring Meeting -Fullerenes and Nanotubes: Materials for the New Chemical Frontier - International Symposium on Fullerenes, Nanotubes, and Carbon Nanoclusters - San Antonio, TX, United States Duration: May 9 2004 → May 13 2004

Other

Other	ECS Annual Spring Meeting -Fullerenes and Nanotubes: Materials for the New Chemical Frontier - International Symposium on Fullerenes, Nanotubes, and Carbon Nanoclusters
Country/Territory	United States
City	San Antonio, TX
Period	5/9/04 → 5/13/04

ASJC Scopus subject areas

General Engineering

Cite this

Zakharian, T., Ashcroft, J., Mirakyan, A., Tsyboulski, D., Benedict, N., Weisman, B., Wilson, L. J., Marks, J. W., & Rosenblum, M. R. (2004). Toward targeted fullerene cancer therapy: Design and synthesis of a Paclitaxel-C₆₀-Antibody conjugate. 338-348. Paper presented at ECS Annual Spring Meeting -Fullerenes and Nanotubes: Materials for the New Chemical Frontier - International Symposium on Fullerenes, Nanotubes, and Carbon Nanoclusters, San Antonio, TX, United States.

Toward targeted fullerene cancer therapy: Design and synthesis of a Paclitaxel-C₆₀-Antibody conjugate. / Zakharian, Tatiana; Ashcroft, Jared; Mirakyan, Andrey et al.
2004. 338-348 Paper presented at ECS Annual Spring Meeting -Fullerenes and Nanotubes: Materials for the New Chemical Frontier - International Symposium on Fullerenes, Nanotubes, and Carbon Nanoclusters, San Antonio, TX, United States.

Research output: Contribution to conference › Paper › peer-review

Zakharian, T, Ashcroft, J, Mirakyan, A, Tsyboulski, D, Benedict, N, Weisman, B, Wilson, LJ, Marks, JW & Rosenblum, MR 2004, 'Toward targeted fullerene cancer therapy: Design and synthesis of a Paclitaxel-C₆₀-Antibody conjugate', Paper presented at ECS Annual Spring Meeting -Fullerenes and Nanotubes: Materials for the New Chemical Frontier - International Symposium on Fullerenes, Nanotubes, and Carbon Nanoclusters, San Antonio, TX, United States, 5/9/04 - 5/13/04 pp. 338-348.

Zakharian T, Ashcroft J, Mirakyan A, Tsyboulski D, Benedict N, Weisman B et al.. Toward targeted fullerene cancer therapy: Design and synthesis of a Paclitaxel-C₆₀-Antibody conjugate. 2004. Paper presented at ECS Annual Spring Meeting -Fullerenes and Nanotubes: Materials for the New Chemical Frontier - International Symposium on Fullerenes, Nanotubes, and Carbon Nanoclusters, San Antonio, TX, United States.

Zakharian, Tatiana ; Ashcroft, Jared ; Mirakyan, Andrey et al. / Toward targeted fullerene cancer therapy : Design and synthesis of a Paclitaxel-C₆₀-Antibody conjugate. Paper presented at ECS Annual Spring Meeting -Fullerenes and Nanotubes: Materials for the New Chemical Frontier - International Symposium on Fullerenes, Nanotubes, and Carbon Nanoclusters, San Antonio, TX, United States.11 p.

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abstract = "Paclitaxel (Taxol) has been successfully used for treating various types of cancers. A Paclitaxel-C60 conjugate has been synthesized as a derivative of Paclitaxel designed to modify the drug delivery rate. In addition, the Paclitaxel-C60 conjugate is being developed for targeted immunotherapy using antibodies. Toward this purpose, a synthetic route has also been developed to covalently couple C60 and its derivatives to the murine anti-gp 240 antibody, which targets melanoma cells. Triplet-triplet absorption spectroscopy of the C60 chromophore is being explored as a method to characterize and trace C60-antibody conjugates in vitro. Current progress toward the synthesis and characterization of a Paclitaxel-C60-Antibody conjugate is reported.",

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AU - Zakharian, Tatiana

AU - Ashcroft, Jared

AU - Mirakyan, Andrey

AU - Tsyboulski, Dmitry

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AU - Weisman, Bruce

AU - Wilson, Lon J.

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Toward targeted fullerene cancer therapy: Design and synthesis of a Paclitaxel-C₆₀-Antibody conjugate

Abstract

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ASJC Scopus subject areas

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