Transcatheter arterial embolization for malignant osseous and soft tissue sarcomas. II. Clinical results

Yasushi Nagata, Michihide Mitsumori, Kaoru Okajima, Takashi Mizowaki, Kazuhisa Fujiwara, Keisuke Sasai, Yasumasa Nishimura, Masahiro Hiraoka, Mitsuyuki Abe, Katsuji Shimizu, Yoshihiko Kotoura

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    Abstract

    Purpose: To evaluate the clinical effects of transcatheter arterial embolization (TAE) on malignant bone and soft tissue tumors. Methods: TAE was performed in 10 patients with primary bone and soft tissue satcomas and in 31 patients with metastatic bone tumors. The embolized arteries were the internal iliac artery in 30 cases, the intercostal artery in six cases, the lumbar artery in five cases, the suprascapular artery in three cases, and the iliolumbar artery, the internal pudendal artery, and the lateral sacral artery in one case each. The embolized material was gelatin sponge particles. The chemotherapeutic drugs were usually 20-40 mg of doxorubicin for primary and metastatic tumors and 50-100 mg of cisplatin only for primary tumors. In addition, 50-60 Gy of 10-MV radiotherapy with or without radiofrequency (RF)- capacitive hyperthermia in four sessions was administered before TAE for primary tumors only. Results: Even though the pain score increased immediately after TAE, 30 of 38 (79%) patients with pain (8 of 9 with primary tumors, and 22 of 29 with metastases) achieved pain control after TAE. A necrotic low-density area shown by computed tomography (CT) after TAE was found in 31 of 41 (76%) tumors [8 of 10 (80%) with primary tumors, and 23 of 31 (74%) with metastatic tumors]. The tumor size decreased in 14 of 25 (56%) primary and metastatic tumors after 3 months. Osteosclerotic changes appeared in two cases of metastatic tumors after 6 months. In five tumors resected after TAE, large areas of necrosis within the tumor were confirmed histologically. Transient local pain and numbness appeared after TAE, but were relieved by drug treatment within 1 week. No severe complications except a case of gluteal muscle necrosis were encountered after TAE. The 1-year survival rate of the patients with primary tumors was 38.1%, and the median survival was 18 months. The longest survival was 84 months. The 1-year survival rate of the patients with metastatic bone tumors was 38.9%; the median survival was 12 months. The longest survival was 24 months. Conclusion: TAE could be an effective treatment for pain control and local control of malignant bone and soft-tissue tumors.

    Original languageEnglish (US)
    Pages (from-to)208-213
    Number of pages6
    JournalCardiovascular and Interventional Radiology
    Volume21
    Issue number3
    DOIs
    StatePublished - Jan 1 1998

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    Keywords

    • Bone tumors
    • Metastases
    • Pain control
    • Radiotherapy
    • Soft tissue sarcoma
    • Transcatheter arterial embolization

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Cardiology and Cardiovascular Medicine

    Cite this

    Nagata, Y., Mitsumori, M., Okajima, K., Mizowaki, T., Fujiwara, K., Sasai, K., Nishimura, Y., Hiraoka, M., Abe, M., Shimizu, K., & Kotoura, Y. (1998). Transcatheter arterial embolization for malignant osseous and soft tissue sarcomas. II. Clinical results. Cardiovascular and Interventional Radiology, 21(3), 208-213. https://doi.org/10.1007/s002709900246