Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis

Paolo Anderlini; Donna Przepiorka; David Seong; Richard Champlin; Martin Körbling

doi:10.1046/j.1365-2141.1996.d01-1778.x

Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis

Paolo Anderlini
, Donna Przepiorka
, David Seong
, Richard Champlin
, Martin Körbling

Stem Cell Transplantation

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Thirteen normal adult donors underwent daily leukapheresis for peripheral blood progenitor cell collection for allografting beginning on day 4 or 5 of G-CSF mobilization (12 μg/kg/d). They had complete blood counts performed 7-10 d after the completion of the procedure. A reduction in the total leucocyte count below baseline levels, accounted for by a decrease in the absolute neutrophil (ANC) and lymphocyte counts, was noted. Neutropenia (ANC < 1.5 x 10⁹/l) occurred in two (15%) of the donors. The lowest ANC observed was 0.6 x 10⁹/l. The neutropenia was asymptomatic and resolved on follow-up evaluation.

Original language	English (US)
Pages (from-to)	155-158
Number of pages	4
Journal	British Journal of Haematology
Volume	94
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2141.1996.d01-1778.x
State	Published - 1996

Keywords

Allogeneic blood stem cell transplantation
Granulocyte colony-stimulating factor
Neutropenia
Normal donors
Peripheral blood stem cell mobilization

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.1996.d01-1778.x

Cite this

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title = "Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis",

abstract = "Thirteen normal adult donors underwent daily leukapheresis for peripheral blood progenitor cell collection for allografting beginning on day 4 or 5 of G-CSF mobilization (12 μg/kg/d). They had complete blood counts performed 7-10 d after the completion of the procedure. A reduction in the total leucocyte count below baseline levels, accounted for by a decrease in the absolute neutrophil (ANC) and lymphocyte counts, was noted. Neutropenia (ANC < 1.5 x 109/l) occurred in two (15\%) of the donors. The lowest ANC observed was 0.6 x 109/l. The neutropenia was asymptomatic and resolved on follow-up evaluation.",

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AU - Seong, David

AU - Champlin, Richard

AU - Körbling, Martin

PY - 1996

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AB - Thirteen normal adult donors underwent daily leukapheresis for peripheral blood progenitor cell collection for allografting beginning on day 4 or 5 of G-CSF mobilization (12 μg/kg/d). They had complete blood counts performed 7-10 d after the completion of the procedure. A reduction in the total leucocyte count below baseline levels, accounted for by a decrease in the absolute neutrophil (ANC) and lymphocyte counts, was noted. Neutropenia (ANC < 1.5 x 109/l) occurred in two (15%) of the donors. The lowest ANC observed was 0.6 x 109/l. The neutropenia was asymptomatic and resolved on follow-up evaluation.

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KW - Granulocyte colony-stimulating factor

KW - Neutropenia

KW - Normal donors

KW - Peripheral blood stem cell mobilization

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Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis

Abstract

Keywords

ASJC Scopus subject areas

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