TY - JOUR
T1 - Transition zone prostate cancer
T2 - Metabolic characteristics at 1H MR spectroscopic imaging-initial results
AU - Zakian, Kristen L.
AU - Eberhardt, Steven
AU - Hricak, Hedvig
AU - Shukla-Dave, Amita
AU - Kleinman, Shanon
AU - Muruganandham, Manickam
AU - Sircar, Kanishka
AU - Kattan, Michael W.
AU - Reuter, Victor E.
AU - Scardino, Peter T.
AU - Koutcher, Jason A.
PY - 2003/10/1
Y1 - 2003/10/1
N2 - PURPOSE: To determine whether cancers of the prostate transition zone (TZ) possess a unique metabolic pattern by which they may be identified at proton magnetic resonance (MR) spectroscopic imaging. MATERIALS AND METHODS: Findings in 40 patients who underwent combined endorectal MR imaging and hydrogen 1 MR spectroscopic imaging before radical prostatectomy and who had TZ tumor identified subsequently at step-section pathologic analysis were retrospectively reviewed. Within this population, a subset of 16 patients whose TZ tumor had a largest diameter of 1 cm or greater and was included in the MR spectroscopic imaging excitation volume was identified. In these 16 patients, the ratios of choline-containing compounds (Cho) and creatine/phosphocreatine (Cr) to citrate (Cit) (ie, [Cho + Cr]/Cit), Cho/Cr, and Cho/Cit were compared in tumor and control tissues. The presence of only Cho and the absence of all metabolites were also assessed. RESULTS: The mean values of (Cho + Cr)/Cit, Cho/Cr, and Cho/Cit were different between TZ cancer and control tissues (P = .001, P = .003, and P = .001, respectively; Wilcoxon signed rank test). Nine (56%) of 16 patients had at least one tumor voxel in which Cho comprised the only detectable peak, while no control voxels showed only Cho (P = .008, McNemar test). The percentage of voxels in which no metabolites were detected did not differ between tumor and control tissues (P = .134, McNemar test). CONCLUSION: TZ cancer has a metabolic profile that is different from that of benign TZ tissue; however, the broad range of metabolite ratios observed in TZ cancer precludes the use of a single ratio to differentiate TZ cancer from benign TZ tissue.
AB - PURPOSE: To determine whether cancers of the prostate transition zone (TZ) possess a unique metabolic pattern by which they may be identified at proton magnetic resonance (MR) spectroscopic imaging. MATERIALS AND METHODS: Findings in 40 patients who underwent combined endorectal MR imaging and hydrogen 1 MR spectroscopic imaging before radical prostatectomy and who had TZ tumor identified subsequently at step-section pathologic analysis were retrospectively reviewed. Within this population, a subset of 16 patients whose TZ tumor had a largest diameter of 1 cm or greater and was included in the MR spectroscopic imaging excitation volume was identified. In these 16 patients, the ratios of choline-containing compounds (Cho) and creatine/phosphocreatine (Cr) to citrate (Cit) (ie, [Cho + Cr]/Cit), Cho/Cr, and Cho/Cit were compared in tumor and control tissues. The presence of only Cho and the absence of all metabolites were also assessed. RESULTS: The mean values of (Cho + Cr)/Cit, Cho/Cr, and Cho/Cit were different between TZ cancer and control tissues (P = .001, P = .003, and P = .001, respectively; Wilcoxon signed rank test). Nine (56%) of 16 patients had at least one tumor voxel in which Cho comprised the only detectable peak, while no control voxels showed only Cho (P = .008, McNemar test). The percentage of voxels in which no metabolites were detected did not differ between tumor and control tissues (P = .134, McNemar test). CONCLUSION: TZ cancer has a metabolic profile that is different from that of benign TZ tissue; however, the broad range of metabolite ratios observed in TZ cancer precludes the use of a single ratio to differentiate TZ cancer from benign TZ tissue.
KW - Magnetic resonance (MR) spectroscopy
KW - Magnetic resonance (MR), tissue characterization
KW - Prostate, MR
KW - Prostate, hyperplasia
KW - Prostate, neoplasms
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U2 - 10.1148/radiol.2291021383
DO - 10.1148/radiol.2291021383
M3 - Article
C2 - 12920178
AN - SCOPUS:0141629547
SN - 0033-8419
VL - 229
SP - 241
EP - 247
JO - Radiology
JF - Radiology
IS - 1
ER -