Abstract
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus with devastating outcomes seen recently in the Americas due to the association of maternal ZIKV infection with fetal microcephaly and other fetal malformations not previously associated with flavivirus infections. Here, we have developed the olive baboon (Papio anubis) as a nonhuman primate (NHP) translational model for the study of ZIKV pathogenesis and associated disease outcomes to contrast and compare with humans and other major NHPs, such as macaques. Following subcutaneous inoculation of adult male and nonpregnant female baboons, viremia was detected at 3 and 4 days postinfection (dpi) with the concordant presentation of a visible rash and conjunctivitis, similar to human ZIKV infection. Furthermore, virus was detected in the mucosa and cerebrospinal fluid. A robust ZIKV-specific IgM and IgG antibody response was also observed in all the animals. These data show striking similarity between humans and the olive baboon following infection with ZIKV, suggesting our model is a suitable translational NHP model to study ZIKV pathogenesis and potential therapeutics.
Original language | English (US) |
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Article number | e00186-18 |
Journal | Journal of Virology |
Volume | 92 |
Issue number | 16 |
DOIs | |
State | Published - Aug 1 2018 |
Keywords
- Baboon
- Flavivirus
- Nonhuman primate
- West Nile virus
- ZIKV
- Zika virus
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology