TY - JOUR
T1 - Treatment regret and quality of life following radical prostatectomy
AU - Ratcliff, Chelsea G.
AU - Cohen, Lorenzo
AU - Pettaway, Curtis A.
AU - Parker, Patricia A.
N1 - Funding Information:
Acknowledgments This project was supported by a research grant from the National Institutes of Health/National Cancer Institute (RO1 MH59432), the National Institutes of Health (CA016672), and a cancer prevention fellowship for Chelsea G. Ratcliff from the National Cancer Institute (R25T CA57730, Shine Chang, PhD, Principle Investigator). We are indebted to Dr. Andy Baum who helped to start it all. We thank Drs. Richard Babaian, Louis Pisters, and Brian Miles for opening up this trial to their patients, Dr. Danielle Carr for study oversight, and Adoneca Fortier for helping with data collection.
PY - 2013/12
Y1 - 2013/12
N2 - Purpose: Negative physical functioning outcomes including incontinence and erectile dysfunction are relatively common following radical prostatectomy (RP) and are associated with treatment regret and compromised quality of life (QOL). The role that treatment regret may have in influencing the association between prostate-specific QOL (i.e., sexual, urinary, bowl functioning) and general QOL following RP has not been examined. Method: This study examined the associations of treatment regret, general QOL (36-item Short Form Health Survey physical and mental health (MCS) composite scores), and prostate-specific QOL (Prostate Cancer QOL sexual, urinary, bowl functioning, and cancer worry subscales) in 95 men who underwent RP for prostate cancer. Results: Multiple regression analyses indicated that poorer sexual and urinary functioning was associated with poorer MCS. Additionally, men with lower sexual and urinary functioning reported greater treatment regret. Treatment regret was also associated with lower MCS. Finally, treatment regret partially mediated the effects of both sexual and urinary functioning on MCS. Conclusions: These findings suggest that regardless of a patient's prostate-specific QOL, reducing treatment regret may improve mental health following RP. Though there are limited options to alter patients' sexual or urinary functioning following RP, treatment regret may be a modifiable contributor to post-surgical adjustment and QOL.
AB - Purpose: Negative physical functioning outcomes including incontinence and erectile dysfunction are relatively common following radical prostatectomy (RP) and are associated with treatment regret and compromised quality of life (QOL). The role that treatment regret may have in influencing the association between prostate-specific QOL (i.e., sexual, urinary, bowl functioning) and general QOL following RP has not been examined. Method: This study examined the associations of treatment regret, general QOL (36-item Short Form Health Survey physical and mental health (MCS) composite scores), and prostate-specific QOL (Prostate Cancer QOL sexual, urinary, bowl functioning, and cancer worry subscales) in 95 men who underwent RP for prostate cancer. Results: Multiple regression analyses indicated that poorer sexual and urinary functioning was associated with poorer MCS. Additionally, men with lower sexual and urinary functioning reported greater treatment regret. Treatment regret was also associated with lower MCS. Finally, treatment regret partially mediated the effects of both sexual and urinary functioning on MCS. Conclusions: These findings suggest that regardless of a patient's prostate-specific QOL, reducing treatment regret may improve mental health following RP. Though there are limited options to alter patients' sexual or urinary functioning following RP, treatment regret may be a modifiable contributor to post-surgical adjustment and QOL.
KW - Prostate cancer
KW - Psychosocial adjustment
KW - QOL
KW - Treatment regret
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U2 - 10.1007/s00520-013-1906-4
DO - 10.1007/s00520-013-1906-4
M3 - Article
C2 - 23907238
AN - SCOPUS:84889097082
SN - 0941-4355
VL - 21
SP - 3337
EP - 3343
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 12
ER -